How Bacteria Subvert Animal Cell Structure and Function

Alyssa Jimenez, Didi Chen, Neal M. Alto

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Bacterial pathogens encode a wide variety of effectors and toxins that hijack host cell structure and function. Of particular importance are virulence factors that target actin cytoskeleton dynamics critical for cell shape, stability, motility, phagocytosis, and division. In addition, many bacteria target organelles of the general secretory pathway (e.g., the endoplasmic reticulum and the Golgi complex) and recycling pathways (e.g., the endolysosomal system) to establish and maintain an intracellular replicative niche. Recent research on the biochemistry and structural biology of bacterial effector proteins and toxins has begun to shed light on the molecular underpinnings of these host-pathogen interactions. This exciting work is revealing how pathogens gain control of the complex and dynamic host cellular environments, which impacts our understanding of microbial infectious disease, immunology, and human cell biology.

Original languageEnglish (US)
Pages (from-to)373-397
Number of pages25
JournalAnnual Review of Cell and Developmental Biology
Volume32
DOIs
StatePublished - Oct 6 2016

Keywords

  • Actin cytoskeleton
  • Bacterial effectors
  • Bacterial toxins
  • Endosomal lysosomal trafficking
  • Golgi complex

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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