Human bocavirus: Clinical significance and implications

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: Human bocavirus (HBoV), a parvovirus, was discovered in 2005 with the use of nonspecific genome amplification techniques. Since its discovery, HBoV has been identified worldwide. This review will focus on the epidemiology and clinical features associated with HBoV infection. RECENT FINDINGS: Initial studies demonstrated the presence of HBoV DNA in respiratory specimens of individuals with respiratory tract disease. Data from some studies suggest that HBoV may be the etiological agent responsible for respiratory tract disease, particularly in young children. HBoV, however, is frequently detected in the presence of other common respiratory viruses. HBoV is not confined to the respiratory tract as evidence of the virus has been detected in serum and stool, the significance of which remains unclear. Presence of the virus in respiratory secretions, serum and stool suggests that this virus may cause systemic illness. SUMMARY: HBoV is an emerging human parvovirus. The full spectrum of disease associated with HBoV remains to be defined.

Original languageEnglish (US)
Pages (from-to)62-66
Number of pages5
JournalCurrent Opinion in Pediatrics
Volume20
Issue number1
DOIs
StatePublished - Feb 2008

Fingerprint

Human bocavirus
Viruses
Respiratory Tract Diseases
Parvovirus
Serum
Respiratory System
Epidemiology
Genome

Keywords

  • Gastrointestinal disease
  • Human bocavirus
  • Human parvovirus
  • Respiratory tract disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Human bocavirus : Clinical significance and implications. / Kahn, Jeffrey.

In: Current Opinion in Pediatrics, Vol. 20, No. 1, 02.2008, p. 62-66.

Research output: Contribution to journalArticle

@article{23fbc32ede204e518483082ae69bcbbd,
title = "Human bocavirus: Clinical significance and implications",
abstract = "PURPOSE OF REVIEW: Human bocavirus (HBoV), a parvovirus, was discovered in 2005 with the use of nonspecific genome amplification techniques. Since its discovery, HBoV has been identified worldwide. This review will focus on the epidemiology and clinical features associated with HBoV infection. RECENT FINDINGS: Initial studies demonstrated the presence of HBoV DNA in respiratory specimens of individuals with respiratory tract disease. Data from some studies suggest that HBoV may be the etiological agent responsible for respiratory tract disease, particularly in young children. HBoV, however, is frequently detected in the presence of other common respiratory viruses. HBoV is not confined to the respiratory tract as evidence of the virus has been detected in serum and stool, the significance of which remains unclear. Presence of the virus in respiratory secretions, serum and stool suggests that this virus may cause systemic illness. SUMMARY: HBoV is an emerging human parvovirus. The full spectrum of disease associated with HBoV remains to be defined.",
keywords = "Gastrointestinal disease, Human bocavirus, Human parvovirus, Respiratory tract disease",
author = "Jeffrey Kahn",
year = "2008",
month = "2",
doi = "10.1097/MOP.0b013e3282f3f518",
language = "English (US)",
volume = "20",
pages = "62--66",
journal = "Current Opinion in Pediatrics",
issn = "1040-8703",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Human bocavirus

T2 - Clinical significance and implications

AU - Kahn, Jeffrey

PY - 2008/2

Y1 - 2008/2

N2 - PURPOSE OF REVIEW: Human bocavirus (HBoV), a parvovirus, was discovered in 2005 with the use of nonspecific genome amplification techniques. Since its discovery, HBoV has been identified worldwide. This review will focus on the epidemiology and clinical features associated with HBoV infection. RECENT FINDINGS: Initial studies demonstrated the presence of HBoV DNA in respiratory specimens of individuals with respiratory tract disease. Data from some studies suggest that HBoV may be the etiological agent responsible for respiratory tract disease, particularly in young children. HBoV, however, is frequently detected in the presence of other common respiratory viruses. HBoV is not confined to the respiratory tract as evidence of the virus has been detected in serum and stool, the significance of which remains unclear. Presence of the virus in respiratory secretions, serum and stool suggests that this virus may cause systemic illness. SUMMARY: HBoV is an emerging human parvovirus. The full spectrum of disease associated with HBoV remains to be defined.

AB - PURPOSE OF REVIEW: Human bocavirus (HBoV), a parvovirus, was discovered in 2005 with the use of nonspecific genome amplification techniques. Since its discovery, HBoV has been identified worldwide. This review will focus on the epidemiology and clinical features associated with HBoV infection. RECENT FINDINGS: Initial studies demonstrated the presence of HBoV DNA in respiratory specimens of individuals with respiratory tract disease. Data from some studies suggest that HBoV may be the etiological agent responsible for respiratory tract disease, particularly in young children. HBoV, however, is frequently detected in the presence of other common respiratory viruses. HBoV is not confined to the respiratory tract as evidence of the virus has been detected in serum and stool, the significance of which remains unclear. Presence of the virus in respiratory secretions, serum and stool suggests that this virus may cause systemic illness. SUMMARY: HBoV is an emerging human parvovirus. The full spectrum of disease associated with HBoV remains to be defined.

KW - Gastrointestinal disease

KW - Human bocavirus

KW - Human parvovirus

KW - Respiratory tract disease

UR - http://www.scopus.com/inward/record.url?scp=38149135882&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38149135882&partnerID=8YFLogxK

U2 - 10.1097/MOP.0b013e3282f3f518

DO - 10.1097/MOP.0b013e3282f3f518

M3 - Article

C2 - 18197041

AN - SCOPUS:38149135882

VL - 20

SP - 62

EP - 66

JO - Current Opinion in Pediatrics

JF - Current Opinion in Pediatrics

SN - 1040-8703

IS - 1

ER -