Human natural killer cells enhance a mixed leukocyte reaction

J. C. Weissler, W. C. Yarbrough, G. B. Toews, L. P. Nicod

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Abstract

Natural killer cells (NK) have been reported to down-regulate the initiation of T cell responses in animal models. In the current study, highly purified CD16+ human NK cells were obtained by cell sorting and their effect on the stimulation of allogeneic T cells (MLR) determined. NK cells did not directly stimulate T cell proliferation. However, when added to a population of loosely adherent mononuclear cells (LAM), NK enhanced the ability of these accessory cells to stimulate T proliferation. This effect was not reproduced by the addition of sorted CD5+ T cells, sorted CD16- cells, or control lymphocytes to the MLR. The effect of NK on the MLR was not restricted by class II antigens and was similar to the effect of adding IL-1 to MLR cultures. These results demonstrate that human NK cells are capable of enhancing a T cell response.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalJournal of Leukocyte Biology
Volume43
Issue number4
StatePublished - 1988

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Mixed Lymphocyte Culture Test
Natural Killer Cells
T-Lymphocytes
Histocompatibility Antigens Class II
Interleukin-1
Down-Regulation
Animal Models
Cell Proliferation
Lymphocytes
Population

ASJC Scopus subject areas

  • Cell Biology

Cite this

Human natural killer cells enhance a mixed leukocyte reaction. / Weissler, J. C.; Yarbrough, W. C.; Toews, G. B.; Nicod, L. P.

In: Journal of Leukocyte Biology, Vol. 43, No. 4, 1988, p. 291-298.

Research output: Contribution to journalArticle

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