Hyaline-Vascular Type Castleman’s Disease, Sarcoidosis, and Crohns Disease

Arjun Gupta, Balaji Ayyar, Hamid Zia, Weina Chen, Samar Harris, Harris V. Naina

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Sarcoidosis and Crohns disease have been associated with increased long term risk of lymphoproliferative disorders, including lymphomas. Newly developed lymphadenopathy in a patient with these disorders should prompt pathological evaluation. Castleman’s disease is a lymphoproliferative disorder characterized by enlarged hyperplastic lymph nodes with regressed follicles surrounded by expanded mantle zones of small lymphocytes, and interfollicular vascular proliferation in the hyaline-vascular type. Similar to sarcoidosis and Crohns disease, its etiology is incompletely understood, although immune dysregulation, genetic factors and infectious and environmental factors are thought to play a role in all three diseases. Interleukin-6 is a possible pathological common factor between these three disease processed. Unicentric, hyaline-vascular type Castleman’s disease can be treated successfully with complete surgical resection. We report a patient with long history of sarcoidosis and Crohns disease with newly developed lymphadenopathy which was found to be due to Castleman’s disease.

Original languageEnglish (US)
JournalIndian Journal of Hematology and Blood Transfusion
DOIs
StateAccepted/In press - Sep 1 2015

Fingerprint

Giant Lymph Node Hyperplasia
Hyalin
Sarcoidosis
Crohn Disease
Blood Vessels
Lymphoproliferative Disorders
Vascular Diseases
Interleukin-6
Lymphoma
Lymph Nodes
Lymphocytes
Lymphadenopathy

Keywords

  • Castleman’s disease
  • Crohns disease
  • Sarcoidosis
  • Surgical resection

ASJC Scopus subject areas

  • Hematology

Cite this

Hyaline-Vascular Type Castleman’s Disease, Sarcoidosis, and Crohns Disease. / Gupta, Arjun; Ayyar, Balaji; Zia, Hamid; Chen, Weina; Harris, Samar; Naina, Harris V.

In: Indian Journal of Hematology and Blood Transfusion, 01.09.2015.

Research output: Contribution to journalArticle

@article{79f892c81ed44b21b026a8ec0e4a78b3,
title = "Hyaline-Vascular Type Castleman’s Disease, Sarcoidosis, and Crohns Disease",
abstract = "Sarcoidosis and Crohns disease have been associated with increased long term risk of lymphoproliferative disorders, including lymphomas. Newly developed lymphadenopathy in a patient with these disorders should prompt pathological evaluation. Castleman’s disease is a lymphoproliferative disorder characterized by enlarged hyperplastic lymph nodes with regressed follicles surrounded by expanded mantle zones of small lymphocytes, and interfollicular vascular proliferation in the hyaline-vascular type. Similar to sarcoidosis and Crohns disease, its etiology is incompletely understood, although immune dysregulation, genetic factors and infectious and environmental factors are thought to play a role in all three diseases. Interleukin-6 is a possible pathological common factor between these three disease processed. Unicentric, hyaline-vascular type Castleman’s disease can be treated successfully with complete surgical resection. We report a patient with long history of sarcoidosis and Crohns disease with newly developed lymphadenopathy which was found to be due to Castleman’s disease.",
keywords = "Castleman’s disease, Crohns disease, Sarcoidosis, Surgical resection",
author = "Arjun Gupta and Balaji Ayyar and Hamid Zia and Weina Chen and Samar Harris and Naina, {Harris V.}",
year = "2015",
month = "9",
day = "1",
doi = "10.1007/s12288-015-0580-8",
language = "English (US)",
journal = "Indian Journal of Hematology and Blood Transfusion",
issn = "0971-4502",
publisher = "Springer India",

}

TY - JOUR

T1 - Hyaline-Vascular Type Castleman’s Disease, Sarcoidosis, and Crohns Disease

AU - Gupta, Arjun

AU - Ayyar, Balaji

AU - Zia, Hamid

AU - Chen, Weina

AU - Harris, Samar

AU - Naina, Harris V.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Sarcoidosis and Crohns disease have been associated with increased long term risk of lymphoproliferative disorders, including lymphomas. Newly developed lymphadenopathy in a patient with these disorders should prompt pathological evaluation. Castleman’s disease is a lymphoproliferative disorder characterized by enlarged hyperplastic lymph nodes with regressed follicles surrounded by expanded mantle zones of small lymphocytes, and interfollicular vascular proliferation in the hyaline-vascular type. Similar to sarcoidosis and Crohns disease, its etiology is incompletely understood, although immune dysregulation, genetic factors and infectious and environmental factors are thought to play a role in all three diseases. Interleukin-6 is a possible pathological common factor between these three disease processed. Unicentric, hyaline-vascular type Castleman’s disease can be treated successfully with complete surgical resection. We report a patient with long history of sarcoidosis and Crohns disease with newly developed lymphadenopathy which was found to be due to Castleman’s disease.

AB - Sarcoidosis and Crohns disease have been associated with increased long term risk of lymphoproliferative disorders, including lymphomas. Newly developed lymphadenopathy in a patient with these disorders should prompt pathological evaluation. Castleman’s disease is a lymphoproliferative disorder characterized by enlarged hyperplastic lymph nodes with regressed follicles surrounded by expanded mantle zones of small lymphocytes, and interfollicular vascular proliferation in the hyaline-vascular type. Similar to sarcoidosis and Crohns disease, its etiology is incompletely understood, although immune dysregulation, genetic factors and infectious and environmental factors are thought to play a role in all three diseases. Interleukin-6 is a possible pathological common factor between these three disease processed. Unicentric, hyaline-vascular type Castleman’s disease can be treated successfully with complete surgical resection. We report a patient with long history of sarcoidosis and Crohns disease with newly developed lymphadenopathy which was found to be due to Castleman’s disease.

KW - Castleman’s disease

KW - Crohns disease

KW - Sarcoidosis

KW - Surgical resection

UR - http://www.scopus.com/inward/record.url?scp=84940570093&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940570093&partnerID=8YFLogxK

U2 - 10.1007/s12288-015-0580-8

DO - 10.1007/s12288-015-0580-8

M3 - Article

C2 - 27408430

AN - SCOPUS:84940570093

JO - Indian Journal of Hematology and Blood Transfusion

JF - Indian Journal of Hematology and Blood Transfusion

SN - 0971-4502

ER -