Hyaluronan biology: A complex balancing act of structure, function, location and context

Stavros Garantziotis; Rashmin C. Savani

doi:10.1016/j.matbio.2019.02.002

Hyaluronan biology: A complex balancing act of structure, function, location and context

Stavros Garantziotis, Rashmin C. Savani

Research output: Contribution to journal › Review article › peer-review

197 Scopus citations

Abstract

Cell-matrix interactions are fundamental to many developmental, homeostatic, immune and pathologic processes. Hyaluronan (HA), a critical component of the extracellular matrix (ECM) that regulates normal structural integrity and development, also regulates tissue responses during injury, repair, and regeneration. Though simple in its primary structure, HA regulates biological responses in a highly complex manner with balanced contributions from its molecular size and concentration, synthesis versus enzymatic and/or oxidative-nitrative fragmentation, interactions with key HA binding proteins and cell associated receptors, and its cell context-specific signaling. This review highlights the different, but inter-related factors that dictate the biological activity of HA and introduces the overarching themes that weave throughout this special issue of Matrix Biology on hyaluronan.

Original language	English (US)
Pages (from-to)	1-10
Number of pages	10
Journal	Matrix Biology
Volume	78-79
DOIs	https://doi.org/10.1016/j.matbio.2019.02.002
State	Published - May 2019
Externally published	Yes

Keywords

Degradation
Hyaluronan
Receptors
Signaling
Structure
Synthesis

ASJC Scopus subject areas

Molecular Biology

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10.1016/j.matbio.2019.02.002

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title = "Hyaluronan biology: A complex balancing act of structure, function, location and context",

abstract = "Cell-matrix interactions are fundamental to many developmental, homeostatic, immune and pathologic processes. Hyaluronan (HA), a critical component of the extracellular matrix (ECM) that regulates normal structural integrity and development, also regulates tissue responses during injury, repair, and regeneration. Though simple in its primary structure, HA regulates biological responses in a highly complex manner with balanced contributions from its molecular size and concentration, synthesis versus enzymatic and/or oxidative-nitrative fragmentation, interactions with key HA binding proteins and cell associated receptors, and its cell context-specific signaling. This review highlights the different, but inter-related factors that dictate the biological activity of HA and introduces the overarching themes that weave throughout this special issue of Matrix Biology on hyaluronan.",

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AU - Garantziotis, Stavros

AU - Savani, Rashmin C.

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N2 - Cell-matrix interactions are fundamental to many developmental, homeostatic, immune and pathologic processes. Hyaluronan (HA), a critical component of the extracellular matrix (ECM) that regulates normal structural integrity and development, also regulates tissue responses during injury, repair, and regeneration. Though simple in its primary structure, HA regulates biological responses in a highly complex manner with balanced contributions from its molecular size and concentration, synthesis versus enzymatic and/or oxidative-nitrative fragmentation, interactions with key HA binding proteins and cell associated receptors, and its cell context-specific signaling. This review highlights the different, but inter-related factors that dictate the biological activity of HA and introduces the overarching themes that weave throughout this special issue of Matrix Biology on hyaluronan.

AB - Cell-matrix interactions are fundamental to many developmental, homeostatic, immune and pathologic processes. Hyaluronan (HA), a critical component of the extracellular matrix (ECM) that regulates normal structural integrity and development, also regulates tissue responses during injury, repair, and regeneration. Though simple in its primary structure, HA regulates biological responses in a highly complex manner with balanced contributions from its molecular size and concentration, synthesis versus enzymatic and/or oxidative-nitrative fragmentation, interactions with key HA binding proteins and cell associated receptors, and its cell context-specific signaling. This review highlights the different, but inter-related factors that dictate the biological activity of HA and introduces the overarching themes that weave throughout this special issue of Matrix Biology on hyaluronan.

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KW - Receptors

KW - Signaling

KW - Structure

KW - Synthesis

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Hyaluronan biology: A complex balancing act of structure, function, location and context

Abstract

Keywords

ASJC Scopus subject areas

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