Hyaluronan biology: A complex balancing act of structure, function, location and context

Stavros Garantziotis, Rashmin C Savani

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Cell-matrix interactions are fundamental to many developmental, homeostatic, immune and pathologic processes. Hyaluronan (HA), a critical component of the extracellular matrix (ECM) that regulates normal structural integrity and development, also regulates tissue responses during injury, repair, and regeneration. Though simple in its primary structure, HA regulates biological responses in a highly complex manner with balanced contributions from its molecular size and concentration, synthesis versus enzymatic and/or oxidative-nitrative fragmentation, interactions with key HA binding proteins and cell associated receptors, and its cell context-specific signaling. This review highlights the different, but inter-related factors that dictate the biological activity of HA and introduces the overarching themes that weave throughout this special issue of Matrix Biology on hyaluronan.

Original languageEnglish (US)
JournalMatrix Biology
DOIs
StatePublished - Jan 1 2019

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Hyaluronic Acid
CD44 Antigens
Biological Factors
Pathologic Processes
Cell Communication
Extracellular Matrix
Regeneration
Wounds and Injuries

Keywords

  • Degradation
  • Hyaluronan
  • Receptors
  • Signaling
  • Structure
  • Synthesis

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Hyaluronan biology : A complex balancing act of structure, function, location and context. / Garantziotis, Stavros; Savani, Rashmin C.

In: Matrix Biology, 01.01.2019.

Research output: Contribution to journalReview article

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