Hypercalcemia and pancreatic endocrine neoplasia with elevated PTH-rP: Report of two new cases and subject review

Susanna L. Matsen, Charles J. Yeo, Ralph H. Hruban, Michael A. Choti

Research output: Contribution to journalArticle

13 Scopus citations


Humoral hypercalcemia of malignancy is widely associated with tumor production of parathyroid hormone related protein (PTH-rP). This peptide functions in endocrine, autocrine and paracrine mechanisms in a manner similar to PTH; increasing renal uptake of calcium, decreasing retention of phosphorous, and stimulating adenylate cyclase and phospholipase C. Although PTH-rP production has been well documented in neoplasms of the exocrine pancreas, we present here two cases of endocrine pancreatic neoplasms elaborating PTH-rP. We then review the literature of previous cases and delve into the pathophysiology of this peptide.

Original languageEnglish (US)
Pages (from-to)270-279
Number of pages10
JournalJournal of Gastrointestinal Surgery
Issue number2
StatePublished - Feb 1 2005



  • Hypercalcemia
  • PTH-rP
  • Pancreatic endocrine neoplasm

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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