Hypertension and the kidney

Michael Wiederkehr, Robert Toto, Andrew Z. Fenves, C. Venkata S Ram

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Hypertension is an important and widely prevalent risk factor for the development of chronic kidney disease (CKD), which unfortunately may progress to end-stage renal disease. CKD is a progressive condition that causes significant morbidity and mortality. Diabetes is the leading cause of end-stage renal disease in the Western world. Both hypertension and diabetes are the causative factors for the occurrence of CKD and its consequences. Aggressive control of hypertension and diabetes is indicated to reduce the risk for kidney disease in the community. Certainly, effective control of hypertension is a proven modality to prevent renal disease. The concept of decreasing the systemic blood pressure as well as the intraglomerular pressure has led to the application of rational therapeutic options in patients with renal insufficiency. Although treatment of hypertension alone is critical, drugs that block the renin-angiotensin system have been shown to have special renal (and cardiovascular) benefits. Early detection and treatment of microalbuminuria is an integral part of disease management. This article reviews the pathophysiologic and therapeutic implications of the link between hypertension and the kidney.

Original languageEnglish (US)
Pages (from-to)236-245
Number of pages10
JournalSeminars in Nephrology
Volume25
Issue number4
DOIs
StatePublished - Jul 2005

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Hypertension
Kidney
Chronic Renal Insufficiency
Chronic Kidney Failure
Western World
Kidney Diseases
Therapeutics
Renin-Angiotensin System
Disease Management
Renal Insufficiency
Blood Pressure
Morbidity
Pressure
Mortality
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Nephrology

Cite this

Wiederkehr, M., Toto, R., Fenves, A. Z., & Ram, C. V. S. (2005). Hypertension and the kidney. Seminars in Nephrology, 25(4), 236-245. https://doi.org/10.1016/j.semnephrol.2005.02.008

Hypertension and the kidney. / Wiederkehr, Michael; Toto, Robert; Fenves, Andrew Z.; Ram, C. Venkata S.

In: Seminars in Nephrology, Vol. 25, No. 4, 07.2005, p. 236-245.

Research output: Contribution to journalArticle

Wiederkehr, M, Toto, R, Fenves, AZ & Ram, CVS 2005, 'Hypertension and the kidney', Seminars in Nephrology, vol. 25, no. 4, pp. 236-245. https://doi.org/10.1016/j.semnephrol.2005.02.008
Wiederkehr, Michael ; Toto, Robert ; Fenves, Andrew Z. ; Ram, C. Venkata S. / Hypertension and the kidney. In: Seminars in Nephrology. 2005 ; Vol. 25, No. 4. pp. 236-245.
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