TY - JOUR
T1 - Hypertrophy and hyperplasia of somatostatin containing D cells in diabetes
AU - Orci, L.
AU - Baetens, D.
AU - Rufener, C.
AU - Amherdt, M.
AU - Ravazzola, M.
AU - Studer, P.
AU - Malaisse-Lagae, F.
AU - Unger, Roger H
PY - 1976
Y1 - 1976
N2 - Insulin, glucagon, and somatostatin containing cells, identified by immunofluorescent staining, were quantitated morphometrically in sections of pancreas obtained from diabetic and nondiabetic humans and rats. Both the volume density and number of somatostatin and glucagon containing cells were significantly increased in the islets of juvenile type human diabetics and of streptozotocin in diabetic rats.
AB - Insulin, glucagon, and somatostatin containing cells, identified by immunofluorescent staining, were quantitated morphometrically in sections of pancreas obtained from diabetic and nondiabetic humans and rats. Both the volume density and number of somatostatin and glucagon containing cells were significantly increased in the islets of juvenile type human diabetics and of streptozotocin in diabetic rats.
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U2 - 10.1073/pnas.73.4.1338
DO - 10.1073/pnas.73.4.1338
M3 - Article
C2 - 131313
AN - SCOPUS:0017065890
VL - 73
SP - 1338
EP - 1342
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 4
ER -