Hypertrophy and hyperplasia of somatostatin containing D cells in diabetes

L. Orci; D. Baetens; C. Rufener; M. Amherdt; M. Ravazzola; P. Studer; F. Malaisse-Lagae; Roger H Unger

doi:10.1073/pnas.73.4.1338

Hypertrophy and hyperplasia of somatostatin containing D cells in diabetes

L. Orci, D. Baetens, C. Rufener, M. Amherdt, M. Ravazzola, P. Studer, F. Malaisse-Lagae, Roger H Unger

Research output: Contribution to journal › Article › peer-review

199 Scopus citations

Abstract

Insulin, glucagon, and somatostatin containing cells, identified by immunofluorescent staining, were quantitated morphometrically in sections of pancreas obtained from diabetic and nondiabetic humans and rats. Both the volume density and number of somatostatin and glucagon containing cells were significantly increased in the islets of juvenile type human diabetics and of streptozotocin in diabetic rats.

Original language	English (US)
Pages (from-to)	1338-1342
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	73
Issue number	4
DOIs	https://doi.org/10.1073/pnas.73.4.1338
State	Published - 1976

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Hypertrophy and hyperplasia of somatostatin containing D cells in diabetes. / Orci, L.; Baetens, D.; Rufener, C.; Amherdt, M.; Ravazzola, M.; Studer, P.; Malaisse-Lagae, F.; Unger, Roger H.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 73, No. 4, 1976, p. 1338-1342.

Research output: Contribution to journal › Article › peer-review

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AU - Studer, P.

AU - Malaisse-Lagae, F.

AU - Unger, Roger H

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