TY - JOUR
T1 - Hypoglossal schwannomas
T2 - A systematic review of the literature
AU - Bindal, Shivani
AU - El Ahmadieh, Tarek Y.
AU - Plitt, Aaron
AU - Aoun, Salah G.
AU - Neeley, Om James
AU - El Tecle, Najib E.
AU - Barnett, Samuel L
AU - Gluf, Wayne M
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Background: Schwannomas of the hypoglossal nerve are rare and account for a very small percentage of non-vestibular schwannomas. Objectives: In this systematic review of the literature, we examined the epidemiology, symptomatology, management, and outcomes of patients with hypoglossal schwannomas. Methods: The electronic database Pubmed was searched for all reports of hypoglossal schwannomas with descriptions of symptoms, management, and outcome characteristics. Data was extracted from each study and compiled in a spreadsheet. Continuous variables were reported as means and medians. Categorical variables were reported as proportions. Additional analysis was not done due to inconsistent reporting of outcomes and small sample sizes. Results: A total of 59 studies (94 total individual cases) were included. 64% of patients were female with mean age of 44.6 years. The majority were intracranial/extracranial (50%). The most common symptoms were tongue deviation or speech disturbance (38%) and headaches (33%). Hypoglossal nerve dysfunction was present in 80% of patients. Surgical excision was performed in 93%, with a 15% complication rate. Evidence of residual mass after surgery was noted in 29%. Permanent hypoglossal nerve deficits occurred in 67%. Recurrence of tumor burden was reported in 6 studies, with median time to recurrence of 16.5 months. Conclusion: Current evidence suggests overall favorable outcomes with surgical resection of hypoglossal schwannomas, with a large percentage of patients experiencing mild and usually well-tolerated neurologic deficit. Limitations of this study include the use of retrospective data taken from case reports/series with highly selected patients, selective reporting, and absence of control groups.
AB - Background: Schwannomas of the hypoglossal nerve are rare and account for a very small percentage of non-vestibular schwannomas. Objectives: In this systematic review of the literature, we examined the epidemiology, symptomatology, management, and outcomes of patients with hypoglossal schwannomas. Methods: The electronic database Pubmed was searched for all reports of hypoglossal schwannomas with descriptions of symptoms, management, and outcome characteristics. Data was extracted from each study and compiled in a spreadsheet. Continuous variables were reported as means and medians. Categorical variables were reported as proportions. Additional analysis was not done due to inconsistent reporting of outcomes and small sample sizes. Results: A total of 59 studies (94 total individual cases) were included. 64% of patients were female with mean age of 44.6 years. The majority were intracranial/extracranial (50%). The most common symptoms were tongue deviation or speech disturbance (38%) and headaches (33%). Hypoglossal nerve dysfunction was present in 80% of patients. Surgical excision was performed in 93%, with a 15% complication rate. Evidence of residual mass after surgery was noted in 29%. Permanent hypoglossal nerve deficits occurred in 67%. Recurrence of tumor burden was reported in 6 studies, with median time to recurrence of 16.5 months. Conclusion: Current evidence suggests overall favorable outcomes with surgical resection of hypoglossal schwannomas, with a large percentage of patients experiencing mild and usually well-tolerated neurologic deficit. Limitations of this study include the use of retrospective data taken from case reports/series with highly selected patients, selective reporting, and absence of control groups.
KW - Cranial nerve 12
KW - Hypoglossal schwannoma
KW - Neck swelling
KW - Peripheral schwannoma
KW - Skull base mass
KW - Twelfth nerve
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U2 - 10.1016/j.jocn.2018.11.037
DO - 10.1016/j.jocn.2018.11.037
M3 - Article
C2 - 30472335
AN - SCOPUS:85056840479
SN - 0967-5868
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
ER -