Hyponatraemia in a neurosurgical patient

Syndrome of inappropriate antidiuretic hormone secretion verses cerebral salt wasting

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86 Citations (Scopus)

Abstract

In summary, SIADH and CSW are two potential causes of hyponatraemia is patients with neurosurgical disorders. Distinguishing between these two disorders can be challenging, since there is considerable overlap in the clinical presentation. The primary distinction lies in the assessment of the EABV. SIADH is a volume expanded state due to ADH-mediated renal water retention. CSW is characterized by a contracted EABV resulting from renal salt wasting. Making an accurate diagnosis is important since the therapy of each condition is quite divergent. Vigorous salt replacement is indicated in patients with CSW while fluid restriction is the treatment of choice in patients with SIADH. Therapy indicated for one disorder but used in the other can potentially result in untoward clinical consequences.

Original languageEnglish (US)
Pages (from-to)262-268
Number of pages7
JournalNephrology Dialysis Transplantation
Volume15
Issue number2
StatePublished - 2000

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Inappropriate ADH Syndrome
Hyponatremia
Salts
Kidney
Therapeutics
Water

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

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abstract = "In summary, SIADH and CSW are two potential causes of hyponatraemia is patients with neurosurgical disorders. Distinguishing between these two disorders can be challenging, since there is considerable overlap in the clinical presentation. The primary distinction lies in the assessment of the EABV. SIADH is a volume expanded state due to ADH-mediated renal water retention. CSW is characterized by a contracted EABV resulting from renal salt wasting. Making an accurate diagnosis is important since the therapy of each condition is quite divergent. Vigorous salt replacement is indicated in patients with CSW while fluid restriction is the treatment of choice in patients with SIADH. Therapy indicated for one disorder but used in the other can potentially result in untoward clinical consequences.",
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AB - In summary, SIADH and CSW are two potential causes of hyponatraemia is patients with neurosurgical disorders. Distinguishing between these two disorders can be challenging, since there is considerable overlap in the clinical presentation. The primary distinction lies in the assessment of the EABV. SIADH is a volume expanded state due to ADH-mediated renal water retention. CSW is characterized by a contracted EABV resulting from renal salt wasting. Making an accurate diagnosis is important since the therapy of each condition is quite divergent. Vigorous salt replacement is indicated in patients with CSW while fluid restriction is the treatment of choice in patients with SIADH. Therapy indicated for one disorder but used in the other can potentially result in untoward clinical consequences.

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