TY - JOUR
T1 - Hyponatraemia in a neurosurgical patient
T2 - Syndrome of inappropriate antidiuretic hormone secretion verses cerebral salt wasting
AU - Palmer, Biff F.
PY - 2000
Y1 - 2000
N2 - In summary, SIADH and CSW are two potential causes of hyponatraemia is patients with neurosurgical disorders. Distinguishing between these two disorders can be challenging, since there is considerable overlap in the clinical presentation. The primary distinction lies in the assessment of the EABV. SIADH is a volume expanded state due to ADH-mediated renal water retention. CSW is characterized by a contracted EABV resulting from renal salt wasting. Making an accurate diagnosis is important since the therapy of each condition is quite divergent. Vigorous salt replacement is indicated in patients with CSW while fluid restriction is the treatment of choice in patients with SIADH. Therapy indicated for one disorder but used in the other can potentially result in untoward clinical consequences.
AB - In summary, SIADH and CSW are two potential causes of hyponatraemia is patients with neurosurgical disorders. Distinguishing between these two disorders can be challenging, since there is considerable overlap in the clinical presentation. The primary distinction lies in the assessment of the EABV. SIADH is a volume expanded state due to ADH-mediated renal water retention. CSW is characterized by a contracted EABV resulting from renal salt wasting. Making an accurate diagnosis is important since the therapy of each condition is quite divergent. Vigorous salt replacement is indicated in patients with CSW while fluid restriction is the treatment of choice in patients with SIADH. Therapy indicated for one disorder but used in the other can potentially result in untoward clinical consequences.
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U2 - 10.1093/ndt/15.2.262
DO - 10.1093/ndt/15.2.262
M3 - Article
C2 - 10648680
AN - SCOPUS:0033971165
SN - 0931-0509
VL - 15
SP - 262
EP - 268
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
IS - 2
ER -