TY - JOUR
T1 - Hypothermia and Persisting Capacity to Develop Fever
T2 - Occurrence in a Patient With Sarcoidosis of the Central Nervous System
AU - Lipton, J. M.
AU - Kirkpatrick, J.
AU - Rosenberg, R. N.
PY - 1977/8
Y1 - 1977/8
N2 - A patient with central nervous system and systemic sarcoidosis had profound hypothermia and dementia with associated lymphadenopathy and hypernatremia. His capacity to develop fever remained; despite the persistent marked hypothermia, sweating and shivering in response to peripheral heating and cooling were maintained. Postmortem neuropathologic studies indicated that the hypothalamic region, generally considered to contain the primary temperature control, had been severely demaged by granulomatous sarcoid disease. These results confirm and extend previous findings of temperature disturbance in hypothalamic sarcoidosis and suggest that the integrity of the primary control of body temperature is not essential to fever production and “broad-band” regulation against environmental temperature extremes.
AB - A patient with central nervous system and systemic sarcoidosis had profound hypothermia and dementia with associated lymphadenopathy and hypernatremia. His capacity to develop fever remained; despite the persistent marked hypothermia, sweating and shivering in response to peripheral heating and cooling were maintained. Postmortem neuropathologic studies indicated that the hypothalamic region, generally considered to contain the primary temperature control, had been severely demaged by granulomatous sarcoid disease. These results confirm and extend previous findings of temperature disturbance in hypothalamic sarcoidosis and suggest that the integrity of the primary control of body temperature is not essential to fever production and “broad-band” regulation against environmental temperature extremes.
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U2 - 10.1001/archneur.1977.00500200058012
DO - 10.1001/archneur.1977.00500200058012
M3 - Article
C2 - 889484
AN - SCOPUS:0017687734
SN - 0003-9942
VL - 34
SP - 498
EP - 504
JO - Archives of neurology
JF - Archives of neurology
IS - 8
ER -