Hypothermia and Persisting Capacity to Develop Fever: Occurrence in a Patient With Sarcoidosis of the Central Nervous System

J. M. Lipton, J. Kirkpatrick, R. N. Rosenberg

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A patient with central nervous system and systemic sarcoidosis had profound hypothermia and dementia with associated lymphadenopathy and hypernatremia. His capacity to develop fever remained; despite the persistent marked hypothermia, sweating and shivering in response to peripheral heating and cooling were maintained. Postmortem neuropathologic studies indicated that the hypothalamic region, generally considered to contain the primary temperature control, had been severely demaged by granulomatous sarcoid disease. These results confirm and extend previous findings of temperature disturbance in hypothalamic sarcoidosis and suggest that the integrity of the primary control of body temperature is not essential to fever production and “broad-band” regulation against environmental temperature extremes.

Original languageEnglish (US)
Pages (from-to)498-504
Number of pages7
JournalArchives of neurology
Volume34
Issue number8
DOIs
StatePublished - Aug 1977

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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