Hypothesis: Is renal allograft rejection initiated by the response to injury sustained during the transplant process

Christopher Y. Lu, Jeffery G. Penfield, Marciusz L. Kielar, Miguel A. Vazquez, D. Rohan Jeyarajah

Research output: Contribution to journalArticle

120 Scopus citations

Abstract

Allograft rejection can be caused by numerous factors such as damage to the donor kidney during surgical removal or implantation, injury sustained during the transport process between the donor and recipient, and suboptimal allograft perfusion during the intra- and post-operative period. In cadaveric allografts, damage can occur during cold storage, during the transit stage between donor and recipient, and hemodynamic instability due to the initial damage that caused its removal from the donor (such as brain death or trauma). We hypothesize that rejection requires recognition of this injury in addition to recognition of alloantigens. If indeed injury proves to be one factor in acute rejection episodes, then therapeutic efforts can be made to reduce injury during the transplantation process.

Original languageEnglish (US)
Pages (from-to)2157-2168
Number of pages12
JournalKidney international
Volume55
Issue number6
DOIs
StatePublished - Jan 1 1999

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Keywords

  • Acute renal failure
  • Chemokine
  • Cytokine
  • T cell
  • Transplantation

ASJC Scopus subject areas

  • Nephrology

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