Hypothesis: Is renal allograft rejection initiated by the response to injury sustained during the transplant process

Christopher Y. Lu, Jeffery G. Penfield, Marciusz L. Kielar, Miguel A. Vazquez, D. Rohan Jeyarajah

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Allograft rejection can be caused by numerous factors such as damage to the donor kidney during surgical removal or implantation, injury sustained during the transport process between the donor and recipient, and suboptimal allograft perfusion during the intra- and post-operative period. In cadaveric allografts, damage can occur during cold storage, during the transit stage between donor and recipient, and hemodynamic instability due to the initial damage that caused its removal from the donor (such as brain death or trauma). We hypothesize that rejection requires recognition of this injury in addition to recognition of alloantigens. If indeed injury proves to be one factor in acute rejection episodes, then therapeutic efforts can be made to reduce injury during the transplantation process.

Original languageEnglish (US)
Pages (from-to)2157-2168
Number of pages12
JournalKidney International
Volume55
Issue number6
DOIs
StatePublished - 1999

Fingerprint

Allografts
Transplants
Kidney
Wounds and Injuries
Brain Death
Isoantigens
Perfusion
Transplantation
Hemodynamics
Therapeutics

Keywords

  • Acute renal failure
  • Chemokine
  • Cytokine
  • T cell
  • Transplantation

ASJC Scopus subject areas

  • Nephrology

Cite this

Hypothesis : Is renal allograft rejection initiated by the response to injury sustained during the transplant process. / Lu, Christopher Y.; Penfield, Jeffery G.; Kielar, Marciusz L.; Vazquez, Miguel A.; Jeyarajah, D. Rohan.

In: Kidney International, Vol. 55, No. 6, 1999, p. 2157-2168.

Research output: Contribution to journalArticle

@article{81752b1139ea4724940e699e9b5d75ce,
title = "Hypothesis: Is renal allograft rejection initiated by the response to injury sustained during the transplant process",
abstract = "Allograft rejection can be caused by numerous factors such as damage to the donor kidney during surgical removal or implantation, injury sustained during the transport process between the donor and recipient, and suboptimal allograft perfusion during the intra- and post-operative period. In cadaveric allografts, damage can occur during cold storage, during the transit stage between donor and recipient, and hemodynamic instability due to the initial damage that caused its removal from the donor (such as brain death or trauma). We hypothesize that rejection requires recognition of this injury in addition to recognition of alloantigens. If indeed injury proves to be one factor in acute rejection episodes, then therapeutic efforts can be made to reduce injury during the transplantation process.",
keywords = "Acute renal failure, Chemokine, Cytokine, T cell, Transplantation",
author = "Lu, {Christopher Y.} and Penfield, {Jeffery G.} and Kielar, {Marciusz L.} and Vazquez, {Miguel A.} and Jeyarajah, {D. Rohan}",
year = "1999",
doi = "10.1046/j.1523-1755.1999.00491.x",
language = "English (US)",
volume = "55",
pages = "2157--2168",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Hypothesis

T2 - Is renal allograft rejection initiated by the response to injury sustained during the transplant process

AU - Lu, Christopher Y.

AU - Penfield, Jeffery G.

AU - Kielar, Marciusz L.

AU - Vazquez, Miguel A.

AU - Jeyarajah, D. Rohan

PY - 1999

Y1 - 1999

N2 - Allograft rejection can be caused by numerous factors such as damage to the donor kidney during surgical removal or implantation, injury sustained during the transport process between the donor and recipient, and suboptimal allograft perfusion during the intra- and post-operative period. In cadaveric allografts, damage can occur during cold storage, during the transit stage between donor and recipient, and hemodynamic instability due to the initial damage that caused its removal from the donor (such as brain death or trauma). We hypothesize that rejection requires recognition of this injury in addition to recognition of alloantigens. If indeed injury proves to be one factor in acute rejection episodes, then therapeutic efforts can be made to reduce injury during the transplantation process.

AB - Allograft rejection can be caused by numerous factors such as damage to the donor kidney during surgical removal or implantation, injury sustained during the transport process between the donor and recipient, and suboptimal allograft perfusion during the intra- and post-operative period. In cadaveric allografts, damage can occur during cold storage, during the transit stage between donor and recipient, and hemodynamic instability due to the initial damage that caused its removal from the donor (such as brain death or trauma). We hypothesize that rejection requires recognition of this injury in addition to recognition of alloantigens. If indeed injury proves to be one factor in acute rejection episodes, then therapeutic efforts can be made to reduce injury during the transplantation process.

KW - Acute renal failure

KW - Chemokine

KW - Cytokine

KW - T cell

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=0032988828&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032988828&partnerID=8YFLogxK

U2 - 10.1046/j.1523-1755.1999.00491.x

DO - 10.1046/j.1523-1755.1999.00491.x

M3 - Article

C2 - 10354265

AN - SCOPUS:0032988828

VL - 55

SP - 2157

EP - 2168

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 6

ER -