Hypothyroidism in older patients with head and neck cancer after treatment with radiation: A population-based study

Grace L. Smith, Benjamin D. Smith, Adam S. Garden, David I. Rosenthal, Steven I. Sherman, William H. Morrison, David L. Schwartz, Randal S. Weber, Thomas A. Buchholz

Research output: Contribution to journalArticle

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Abstract

Background. In patients with head and neck cancer, radiation treatment (RT) is a risk factor for hypothyroidism. However, the specific magnitude of risk after RT in older patients is not known. Methods. We identified 5916 patients (age > 65 years) from SEER-Medicare diagnosed with head and neck cancer from 1992 to 2002. Proportional hazards models compared hypothyroidism risk after any RT versus surgery alone. Results. In patients treated with RT, 5-year incidence of hypothyroidism was 20% and 10-year incidence was 59%; in patients treated with surgery alone, incidence was 7% and 39% (p < .001). Patients treated with RT had increased adjusted risk (hazard ratio [HR] = 2.14; 95% confidence interval [CI] = 1.74-2.62), persisting for up to 10 years of follow-up (HR = 1.85, 95% CI = 1.39-2.44 from 5 to 10 years). Conclusion. In older patients with head and neck cancer, RT is associated with elevated hypothyroidism risk. As onset may be delayed for years, patients may require lifelong thyroid function screening after treatment.

Original languageEnglish (US)
Pages (from-to)1031-1038
Number of pages8
JournalHead and Neck
Volume31
Issue number8
DOIs
StatePublished - Aug 2009

Fingerprint

Head and Neck Neoplasms
Hypothyroidism
Radiation
Population
Therapeutics
Incidence
Confidence Intervals
Medicare
Proportional Hazards Models
Thyroid Gland
Odds Ratio

Keywords

  • Head and neck cancer
  • Hypothyroidism
  • Radiation
  • Survivorship
  • Toxicity

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Smith, G. L., Smith, B. D., Garden, A. S., Rosenthal, D. I., Sherman, S. I., Morrison, W. H., ... Buchholz, T. A. (2009). Hypothyroidism in older patients with head and neck cancer after treatment with radiation: A population-based study. Head and Neck, 31(8), 1031-1038. https://doi.org/10.1002/hed.21066

Hypothyroidism in older patients with head and neck cancer after treatment with radiation : A population-based study. / Smith, Grace L.; Smith, Benjamin D.; Garden, Adam S.; Rosenthal, David I.; Sherman, Steven I.; Morrison, William H.; Schwartz, David L.; Weber, Randal S.; Buchholz, Thomas A.

In: Head and Neck, Vol. 31, No. 8, 08.2009, p. 1031-1038.

Research output: Contribution to journalArticle

Smith, GL, Smith, BD, Garden, AS, Rosenthal, DI, Sherman, SI, Morrison, WH, Schwartz, DL, Weber, RS & Buchholz, TA 2009, 'Hypothyroidism in older patients with head and neck cancer after treatment with radiation: A population-based study', Head and Neck, vol. 31, no. 8, pp. 1031-1038. https://doi.org/10.1002/hed.21066
Smith, Grace L. ; Smith, Benjamin D. ; Garden, Adam S. ; Rosenthal, David I. ; Sherman, Steven I. ; Morrison, William H. ; Schwartz, David L. ; Weber, Randal S. ; Buchholz, Thomas A. / Hypothyroidism in older patients with head and neck cancer after treatment with radiation : A population-based study. In: Head and Neck. 2009 ; Vol. 31, No. 8. pp. 1031-1038.
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