Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the drosophila renal tubule

Yipin Wu, Jeffrey N. Schellinger, Chou Long Huang, Aylin R. Rodan

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Hypotonicity stimulates transepithelial ion and water flux in the Drosophila renal tubule through unknown mechanisms.

Results: The with-no-lysine (WNK) and Ste20-related proline/alanine-rich (SPAK)/oxidative stress response (OSR1) kinase cascade regulates transepithelial K+flux through the fly sodium-potassium-2-chloride cotransporter (NKCC).

Conclusion: The kinase/NKCC pathway is required for the tubule's response to hypotonicity.

Significance: This provides a molecular mechanism by which flies osmoregulate.

Original languageEnglish (US)
Pages (from-to)26131-26142
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number38
DOIs
StatePublished - Sep 19 2014

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Sodium-Potassium-Chloride Symporters
Diptera
Drosophila
Chlorides
Potassium
Phosphotransferases
Sodium
Fluxes
Kidney
Oxidative stress
Proline
Alanine
Lysine
Oxidative Stress
Ions
Water

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

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abstract = "Background: Hypotonicity stimulates transepithelial ion and water flux in the Drosophila renal tubule through unknown mechanisms.Results: The with-no-lysine (WNK) and Ste20-related proline/alanine-rich (SPAK)/oxidative stress response (OSR1) kinase cascade regulates transepithelial K+flux through the fly sodium-potassium-2-chloride cotransporter (NKCC).Conclusion: The kinase/NKCC pathway is required for the tubule's response to hypotonicity.Significance: This provides a molecular mechanism by which flies osmoregulate.",
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T1 - Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the drosophila renal tubule

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AU - Schellinger, Jeffrey N.

AU - Huang, Chou Long

AU - Rodan, Aylin R.

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AB - Background: Hypotonicity stimulates transepithelial ion and water flux in the Drosophila renal tubule through unknown mechanisms.Results: The with-no-lysine (WNK) and Ste20-related proline/alanine-rich (SPAK)/oxidative stress response (OSR1) kinase cascade regulates transepithelial K+flux through the fly sodium-potassium-2-chloride cotransporter (NKCC).Conclusion: The kinase/NKCC pathway is required for the tubule's response to hypotonicity.Significance: This provides a molecular mechanism by which flies osmoregulate.

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