Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the drosophila renal tubule

Yipin Wu, Jeffrey N. Schellinger, Chou Long Huang, Aylin R. Rodan

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Background: Hypotonicity stimulates transepithelial ion and water flux in the Drosophila renal tubule through unknown mechanisms.

Results: The with-no-lysine (WNK) and Ste20-related proline/alanine-rich (SPAK)/oxidative stress response (OSR1) kinase cascade regulates transepithelial K+flux through the fly sodium-potassium-2-chloride cotransporter (NKCC).

Conclusion: The kinase/NKCC pathway is required for the tubule's response to hypotonicity.

Significance: This provides a molecular mechanism by which flies osmoregulate.

Original languageEnglish (US)
Pages (from-to)26131-26142
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number38
DOIs
StatePublished - Sep 19 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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