Background: Hypotonicity stimulates transepithelial ion and water flux in the Drosophila renal tubule through unknown mechanisms.
Results: The with-no-lysine (WNK) and Ste20-related proline/alanine-rich (SPAK)/oxidative stress response (OSR1) kinase cascade regulates transepithelial K+flux through the fly sodium-potassium-2-chloride cotransporter (NKCC).
Conclusion: The kinase/NKCC pathway is required for the tubule's response to hypotonicity.
Significance: This provides a molecular mechanism by which flies osmoregulate.
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology