Abstract
Background: Hypotonicity stimulates transepithelial ion and water flux in the Drosophila renal tubule through unknown mechanisms.
Results: The with-no-lysine (WNK) and Ste20-related proline/alanine-rich (SPAK)/oxidative stress response (OSR1) kinase cascade regulates transepithelial K+flux through the fly sodium-potassium-2-chloride cotransporter (NKCC).
Conclusion: The kinase/NKCC pathway is required for the tubule's response to hypotonicity.
Significance: This provides a molecular mechanism by which flies osmoregulate.
Original language | English (US) |
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Pages (from-to) | 26131-26142 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 38 |
DOIs | |
State | Published - Sep 19 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology