Identification of a distinct family of genes encoding atypical odorant-binding proteins in the malaria vector mosquito, Anopheles gambiae

P. X. Xu, L. J. Zwiebelt, D. P. Smith

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

We performed a genome-wide analysis for candidate odorant-binding protein (OBP) genes in the malaria vector Anopheles gambiae (Ag). We identified fifty-seven putative genes including sixteen genes predicted to encode distinct, higher molecular weight proteins that lack orthologues in Drosophila. Expression analysis indicates that several of these atypical AgOBPs are transcribed in chemosensory organs in adult and immature stages. Phylogenetic analysis of the Anopheles and Drosophila OBP families reveals these proteins fall into several clusters based on sequence similarity and suggests the atypical AgOBP genes arose in the mosquito lineage after the divergence of mosquitoes and flies. The identification of these AgOBP genes is the first step towards determining their biological roles in this economically and medically important insect.

Original languageEnglish (US)
Pages (from-to)549-560
Number of pages12
JournalInsect Molecular Biology
Volume12
Issue number6
DOIs
StatePublished - Dec 2003

Fingerprint

Anopheles gambiae
Gene encoding
malaria
Malaria
Culicidae
Genes
genes
Drosophila
Anopheles
Diptera
Insects
Proteins
proteins
Molecular Weight
immatures
odorant receptors
Mosquito Vectors
odorant-binding protein
Genome
molecular weight

Keywords

  • Invertebrate
  • Olfaction
  • Olfactory
  • Perireceptor
  • Plasmodium
  • Smell

ASJC Scopus subject areas

  • Insect Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Identification of a distinct family of genes encoding atypical odorant-binding proteins in the malaria vector mosquito, Anopheles gambiae. / Xu, P. X.; Zwiebelt, L. J.; Smith, D. P.

In: Insect Molecular Biology, Vol. 12, No. 6, 12.2003, p. 549-560.

Research output: Contribution to journalArticle

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