Identification of an achaete-scute homolog, Fash1, from Fugu rubripes

Sunita Verma-Kurvari, Jane E. Johnson

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Proteins of the achaete-scute family of transcription factors play important roles in neurogenesis in both invertebrates and vertebrates. Here, we report the cloning and characterization of a Japanese pufferfish, Fugu rubripes achaete-scute homolog 1, Fash1. Sequence alignment of the predicted amino acid sequence of Fash1 with other vertebrate homologs of the achaete-scute homolog 1 subclass shows that the carboxyl 2/3 of the protein, including the basic helix-loop-helix, a putative nuclear localization signal and several consensus phosphorylation sites, is highly conserved. Strikingly, the similarity in this region between eight vertebrate species is close to 90%.

Original languageEnglish (US)
Pages (from-to)145-148
Number of pages4
JournalGene
Volume200
Issue number1-2
DOIs
Publication statusPublished - Oct 24 1997

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Keywords

  • bHLH
  • Mash1
  • Transcription factor

ASJC Scopus subject areas

  • Genetics

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