TY - JOUR
T1 - Identification of scavenger receptor SR-BI as a high density lipoprotein receptor
AU - Acton, Susan
AU - Rigotti, Attilio
AU - Landschulz, Katherine T.
AU - Xu, Shangzhe
AU - Hobbs, Helen H.
AU - Kriegert, Monty
PY - 1996/1/26
Y1 - 1996/1/26
N2 - High density lipoprotein (HDL) and low density lipoprotein (LDL) are cholesterol transport particles whose plasma concentrations are directly (LDL) and inversely (HDL) correlated with risk for atherosclerosis. LDL catabolism involves cellular uptake and degradation of the entire particle by a well-characterized receptor. HDL, in contrast, selectively delivers its cholesterol, but not protein, to cells by unknown receptors. Here it is shown that the class B scavenger receptor SR-BI is an HDL receptor. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway.
AB - High density lipoprotein (HDL) and low density lipoprotein (LDL) are cholesterol transport particles whose plasma concentrations are directly (LDL) and inversely (HDL) correlated with risk for atherosclerosis. LDL catabolism involves cellular uptake and degradation of the entire particle by a well-characterized receptor. HDL, in contrast, selectively delivers its cholesterol, but not protein, to cells by unknown receptors. Here it is shown that the class B scavenger receptor SR-BI is an HDL receptor. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway.
UR - http://www.scopus.com/inward/record.url?scp=0030046797&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030046797&partnerID=8YFLogxK
U2 - 10.1126/science.271.5248.518
DO - 10.1126/science.271.5248.518
M3 - Article
C2 - 8560269
AN - SCOPUS:0030046797
SN - 0036-8075
VL - 271
SP - 518
EP - 520
JO - Science
JF - Science
IS - 5248
ER -