TY - JOUR
T1 - Identification, sequence, and expression of caveolin-2 defines a caveolin gene family
AU - Scherer, Philipp E.
AU - Okamoto, Takashi
AU - Chun, Miyoung
AU - Nishimoto, Ikuo
AU - Lodish, Harvey F.
AU - Lisanti, Michael P.
PY - 1996/1/9
Y1 - 1996/1/9
N2 - Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Here, an ≃20-kDa caveolin-related protein, caveolin-2, was identified through microsequencing of adipocyte- derived caveolin-enriched membranes; caveolin was retermed caveolin-1. Caveolins 1 and 2 are similar in most respects. mRNAs for bulb caveolin-1 and caveolin-2 are most abundantly expressed in white adipose tissue and are induced during adipocyte differentiation. Caveolin-2 colocalizes with caveolin-1, indicating that caveolin-2 also localizes to caveolae. However, caveolin-1 and caveolin-2 differ in their functional interactions with heterotrimeric G proteins, possibly explaining why caveolin-1 and -2 are coexpressed within a single cell.
AB - Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Here, an ≃20-kDa caveolin-related protein, caveolin-2, was identified through microsequencing of adipocyte- derived caveolin-enriched membranes; caveolin was retermed caveolin-1. Caveolins 1 and 2 are similar in most respects. mRNAs for bulb caveolin-1 and caveolin-2 are most abundantly expressed in white adipose tissue and are induced during adipocyte differentiation. Caveolin-2 colocalizes with caveolin-1, indicating that caveolin-2 also localizes to caveolae. However, caveolin-1 and caveolin-2 differ in their functional interactions with heterotrimeric G proteins, possibly explaining why caveolin-1 and -2 are coexpressed within a single cell.
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U2 - 10.1073/pnas.93.1.131
DO - 10.1073/pnas.93.1.131
M3 - Article
C2 - 8552590
AN - SCOPUS:0030034772
SN - 0027-8424
VL - 93
SP - 131
EP - 135
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 1
ER -