Identification, sequence, and expression of caveolin-2 defines a caveolin gene family

Philipp E. Scherer, Takashi Okamoto, Miyoung Chun, Ikuo Nishimoto, Harvey F. Lodish, Michael P. Lisanti

Research output: Contribution to journalArticle

454 Citations (Scopus)

Abstract

Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Here, an ≃20-kDa caveolin-related protein, caveolin-2, was identified through microsequencing of adipocyte- derived caveolin-enriched membranes; caveolin was retermed caveolin-1. Caveolins 1 and 2 are similar in most respects. mRNAs for bulb caveolin-1 and caveolin-2 are most abundantly expressed in white adipose tissue and are induced during adipocyte differentiation. Caveolin-2 colocalizes with caveolin-1, indicating that caveolin-2 also localizes to caveolae. However, caveolin-1 and caveolin-2 differ in their functional interactions with heterotrimeric G proteins, possibly explaining why caveolin-1 and -2 are coexpressed within a single cell.

Original languageEnglish (US)
Pages (from-to)131-135
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume93
Issue number1
DOIs
StatePublished - Jan 9 1996

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Caveolin 2
Caveolins
Caveolin 1
Genes
Caveolae
Adipocytes
Heterotrimeric GTP-Binding Proteins
White Adipose Tissue
Guanine Nucleotides
Membranes
GTP-Binding Proteins
Carrier Proteins
Membrane Proteins
Messenger RNA

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. / Scherer, Philipp E.; Okamoto, Takashi; Chun, Miyoung; Nishimoto, Ikuo; Lodish, Harvey F.; Lisanti, Michael P.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, No. 1, 09.01.1996, p. 131-135.

Research output: Contribution to journalArticle

Scherer, Philipp E. ; Okamoto, Takashi ; Chun, Miyoung ; Nishimoto, Ikuo ; Lodish, Harvey F. ; Lisanti, Michael P. / Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. In: Proceedings of the National Academy of Sciences of the United States of America. 1996 ; Vol. 93, No. 1. pp. 131-135.
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