Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites

Y. Pommier, P. N. Cockerill, K. W. Kohn, W. T. Garrard

Research output: Contribution to journalArticle

51 Scopus citations


We demonstrate that the simian virus 40 genome contains a single MAR (matrix association region) that maps within a large T-antigen coding region (nucleotides 4071 to 4377). This region contains topoisomerase II cleavage sites, exhibits sequence similarity with cellular MARs, and recognizes the same evolutionarily conserved, abundant nuclear binding sites seen by cellular MAR.

Original languageEnglish (US)
Pages (from-to)419-423
Number of pages5
JournalJournal of virology
Issue number1
StatePublished - Jan 1 1990


ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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