We demonstrate that the simian virus 40 genome contains a single MAR (matrix association region) that maps within a large T-antigen coding region (nucleotides 4071 to 4377). This region contains topoisomerase II cleavage sites, exhibits sequence similarity with cellular MARs, and recognizes the same evolutionarily conserved, abundant nuclear binding sites seen by cellular MAR.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of virology|
|State||Published - Jan 1 1990|
ASJC Scopus subject areas
- Insect Science