Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites

Y. Pommier; P. N. Cockerill; K. W. Kohn; W. T. Garrard

doi:10.1128/jvi.64.1.419-423.1990

Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites

Y. Pommier, P. N. Cockerill, K. W. Kohn, W. T. Garrard

Molecular Biology

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

We demonstrate that the simian virus 40 genome contains a single MAR (matrix association region) that maps within a large T-antigen coding region (nucleotides 4071 to 4377). This region contains topoisomerase II cleavage sites, exhibits sequence similarity with cellular MARs, and recognizes the same evolutionarily conserved, abundant nuclear binding sites seen by cellular MAR.

Original language	English (US)
Pages (from-to)	419-423
Number of pages	5
Journal	Journal of virology
Volume	64
Issue number	1
DOIs	https://doi.org/10.1128/jvi.64.1.419-423.1990
State	Published - 1990

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.64.1.419-423.1990

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abstract = "We demonstrate that the simian virus 40 genome contains a single MAR (matrix association region) that maps within a large T-antigen coding region (nucleotides 4071 to 4377). This region contains topoisomerase II cleavage sites, exhibits sequence similarity with cellular MARs, and recognizes the same evolutionarily conserved, abundant nuclear binding sites seen by cellular MAR.",

author = "Y. Pommier and Cockerill, {P. N.} and Kohn, {K. W.} and Garrard, {W. T.}",

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AU - Cockerill, P. N.

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AU - Garrard, W. T.

PY - 1990

Y1 - 1990

N2 - We demonstrate that the simian virus 40 genome contains a single MAR (matrix association region) that maps within a large T-antigen coding region (nucleotides 4071 to 4377). This region contains topoisomerase II cleavage sites, exhibits sequence similarity with cellular MARs, and recognizes the same evolutionarily conserved, abundant nuclear binding sites seen by cellular MAR.

AB - We demonstrate that the simian virus 40 genome contains a single MAR (matrix association region) that maps within a large T-antigen coding region (nucleotides 4071 to 4377). This region contains topoisomerase II cleavage sites, exhibits sequence similarity with cellular MARs, and recognizes the same evolutionarily conserved, abundant nuclear binding sites seen by cellular MAR.

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Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites

Abstract

ASJC Scopus subject areas

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