Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites

Y. Pommier, P. N. Cockerill, K. W. Kohn, W. T. Garrard

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

We demonstrate that the simian virus 40 genome contains a single MAR (matrix association region) that maps within a large T-antigen coding region (nucleotides 4071 to 4377). This region contains topoisomerase II cleavage sites, exhibits sequence similarity with cellular MARs, and recognizes the same evolutionarily conserved, abundant nuclear binding sites seen by cellular MAR.

Original languageEnglish (US)
Pages (from-to)419-423
Number of pages5
JournalJournal of Virology
Volume64
Issue number1
StatePublished - 1990

Fingerprint

Simian virus 40
DNA topoisomerase (ATP-hydrolysing)
Type II DNA Topoisomerase
Viral Tumor Antigens
binding sites
Nucleotides
nucleotides
Binding Sites
Genome
antigens
genome

ASJC Scopus subject areas

  • Immunology

Cite this

Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites. / Pommier, Y.; Cockerill, P. N.; Kohn, K. W.; Garrard, W. T.

In: Journal of Virology, Vol. 64, No. 1, 1990, p. 419-423.

Research output: Contribution to journalArticle

Pommier, Y. ; Cockerill, P. N. ; Kohn, K. W. ; Garrard, W. T. / Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites. In: Journal of Virology. 1990 ; Vol. 64, No. 1. pp. 419-423.
@article{4a16d3448c4640d6ae0644372db9eb2a,
title = "Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites",
abstract = "We demonstrate that the simian virus 40 genome contains a single MAR (matrix association region) that maps within a large T-antigen coding region (nucleotides 4071 to 4377). This region contains topoisomerase II cleavage sites, exhibits sequence similarity with cellular MARs, and recognizes the same evolutionarily conserved, abundant nuclear binding sites seen by cellular MAR.",
author = "Y. Pommier and Cockerill, {P. N.} and Kohn, {K. W.} and Garrard, {W. T.}",
year = "1990",
language = "English (US)",
volume = "64",
pages = "419--423",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "1",

}

TY - JOUR

T1 - Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites

AU - Pommier, Y.

AU - Cockerill, P. N.

AU - Kohn, K. W.

AU - Garrard, W. T.

PY - 1990

Y1 - 1990

N2 - We demonstrate that the simian virus 40 genome contains a single MAR (matrix association region) that maps within a large T-antigen coding region (nucleotides 4071 to 4377). This region contains topoisomerase II cleavage sites, exhibits sequence similarity with cellular MARs, and recognizes the same evolutionarily conserved, abundant nuclear binding sites seen by cellular MAR.

AB - We demonstrate that the simian virus 40 genome contains a single MAR (matrix association region) that maps within a large T-antigen coding region (nucleotides 4071 to 4377). This region contains topoisomerase II cleavage sites, exhibits sequence similarity with cellular MARs, and recognizes the same evolutionarily conserved, abundant nuclear binding sites seen by cellular MAR.

UR - http://www.scopus.com/inward/record.url?scp=0025169835&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025169835&partnerID=8YFLogxK

M3 - Article

C2 - 2152827

AN - SCOPUS:0025169835

VL - 64

SP - 419

EP - 423

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 1

ER -