Identifying novel transcriptional components controlling energy metabolism

Rana K Gupta; Evan D. Rosen; Bruce M. Spiegelman

doi:10.1016/j.cmet.2011.11.007

Identifying novel transcriptional components controlling energy metabolism

Rana K Gupta, Evan D. Rosen, Bruce M. Spiegelman

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

The investigation of metabolic regulation at the transcriptional level presents different challenges than those encountered in the study of other important problems like development or cancer. Levels of key components like glucose, insulin, and lipids can be modulated but rarely change in an all-or-none fashion, necessitating quantitative techniques that can be applied to multiple tissues and systems. This review examines recent advances in methods for studying transcriptional regulation, with special emphasis on metabolic science. We compare these methods for investigators trying to decide on the best approach for their particular physiological paradigm or model system.

Original language	English (US)
Pages (from-to)	739-745
Number of pages	7
Journal	Cell Metabolism
Volume	14
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2011.11.007
State	Published - Dec 7 2011

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2011.11.007

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title = "Identifying novel transcriptional components controlling energy metabolism",

abstract = "The investigation of metabolic regulation at the transcriptional level presents different challenges than those encountered in the study of other important problems like development or cancer. Levels of key components like glucose, insulin, and lipids can be modulated but rarely change in an all-or-none fashion, necessitating quantitative techniques that can be applied to multiple tissues and systems. This review examines recent advances in methods for studying transcriptional regulation, with special emphasis on metabolic science. We compare these methods for investigators trying to decide on the best approach for their particular physiological paradigm or model system.",

author = "Gupta, {Rana K} and Rosen, {Evan D.} and Spiegelman, {Bruce M.}",

note = "Funding Information: The authors thank M. Khandekar and S. Kleiner for helpful discussions and P. Cohen for critical reading of the manuscript. The authors are supported by National Institutes of Health (NIH) K01 DK090120-02 to R.K.G., NIH R01 DK31405 to B.M.S., and NIH R01 DK078061 to E.D.R.",

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AU - Rosen, Evan D.

AU - Spiegelman, Bruce M.

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AB - The investigation of metabolic regulation at the transcriptional level presents different challenges than those encountered in the study of other important problems like development or cancer. Levels of key components like glucose, insulin, and lipids can be modulated but rarely change in an all-or-none fashion, necessitating quantitative techniques that can be applied to multiple tissues and systems. This review examines recent advances in methods for studying transcriptional regulation, with special emphasis on metabolic science. We compare these methods for investigators trying to decide on the best approach for their particular physiological paradigm or model system.

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Identifying novel transcriptional components controlling energy metabolism

Abstract

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