Idiopathic polyneuropathy associated with cytotoxic anti neuroblastoma serum. IgG and IgM immunoglobulin studies

R. N. Rosenberg, M. H. Aung, R. S A Tindall, S. Molenich, R. Baskin, J. D. Capra, H. R. Toben

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Sera from 6 patients with progressive idiopathic acute or chronic polyneuropathy possessed a cytolytic activity against transformed mouse cholinergic or noncholinergic neuroblasts but not against transformed rat astrocytes. This activity was not qualitatively present in sera from normal controls or from patients with a variety of other motor system disorders and other neurologic disorders. Fluorescein conjugated goat antihuman IgG and IgM monospecific immunoglobulins were used to characterize further the cytotoxic activity from patient sera and these studies suggested the presence of immunoglobulin G (IgG) and immunoglobulin M (IgM) directed against a cell surface neuroblastoma antigen. Cold reactive immunoglobulins of the IgG and IgM type were present in the sera of all 6 patients. A bioassay is described that may be helpful in evaluating other patients with progressive idiopathic polyneuropathies.

Original languageEnglish (US)
Pages (from-to)1101-1110
Number of pages10
JournalNeurology
Volume25
Issue number12
StatePublished - 1975

Fingerprint

Polyneuropathies
Neuroblastoma
Immunoglobulin M
Immunoglobulins
Immunoglobulin G
Serum
Surface Antigens
Nervous System Diseases
Fluorescein
Goats
Astrocytes
Biological Assay
Cholinergic Agents

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Rosenberg, R. N., Aung, M. H., Tindall, R. S. A., Molenich, S., Baskin, R., Capra, J. D., & Toben, H. R. (1975). Idiopathic polyneuropathy associated with cytotoxic anti neuroblastoma serum. IgG and IgM immunoglobulin studies. Neurology, 25(12), 1101-1110.

Idiopathic polyneuropathy associated with cytotoxic anti neuroblastoma serum. IgG and IgM immunoglobulin studies. / Rosenberg, R. N.; Aung, M. H.; Tindall, R. S A; Molenich, S.; Baskin, R.; Capra, J. D.; Toben, H. R.

In: Neurology, Vol. 25, No. 12, 1975, p. 1101-1110.

Research output: Contribution to journalArticle

Rosenberg, RN, Aung, MH, Tindall, RSA, Molenich, S, Baskin, R, Capra, JD & Toben, HR 1975, 'Idiopathic polyneuropathy associated with cytotoxic anti neuroblastoma serum. IgG and IgM immunoglobulin studies', Neurology, vol. 25, no. 12, pp. 1101-1110.
Rosenberg, R. N. ; Aung, M. H. ; Tindall, R. S A ; Molenich, S. ; Baskin, R. ; Capra, J. D. ; Toben, H. R. / Idiopathic polyneuropathy associated with cytotoxic anti neuroblastoma serum. IgG and IgM immunoglobulin studies. In: Neurology. 1975 ; Vol. 25, No. 12. pp. 1101-1110.
@article{2825c616cd3a40aaad4b85218af4e2c8,
title = "Idiopathic polyneuropathy associated with cytotoxic anti neuroblastoma serum. IgG and IgM immunoglobulin studies",
abstract = "Sera from 6 patients with progressive idiopathic acute or chronic polyneuropathy possessed a cytolytic activity against transformed mouse cholinergic or noncholinergic neuroblasts but not against transformed rat astrocytes. This activity was not qualitatively present in sera from normal controls or from patients with a variety of other motor system disorders and other neurologic disorders. Fluorescein conjugated goat antihuman IgG and IgM monospecific immunoglobulins were used to characterize further the cytotoxic activity from patient sera and these studies suggested the presence of immunoglobulin G (IgG) and immunoglobulin M (IgM) directed against a cell surface neuroblastoma antigen. Cold reactive immunoglobulins of the IgG and IgM type were present in the sera of all 6 patients. A bioassay is described that may be helpful in evaluating other patients with progressive idiopathic polyneuropathies.",
author = "Rosenberg, {R. N.} and Aung, {M. H.} and Tindall, {R. S A} and S. Molenich and R. Baskin and Capra, {J. D.} and Toben, {H. R.}",
year = "1975",
language = "English (US)",
volume = "25",
pages = "1101--1110",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

TY - JOUR

T1 - Idiopathic polyneuropathy associated with cytotoxic anti neuroblastoma serum. IgG and IgM immunoglobulin studies

AU - Rosenberg, R. N.

AU - Aung, M. H.

AU - Tindall, R. S A

AU - Molenich, S.

AU - Baskin, R.

AU - Capra, J. D.

AU - Toben, H. R.

PY - 1975

Y1 - 1975

N2 - Sera from 6 patients with progressive idiopathic acute or chronic polyneuropathy possessed a cytolytic activity against transformed mouse cholinergic or noncholinergic neuroblasts but not against transformed rat astrocytes. This activity was not qualitatively present in sera from normal controls or from patients with a variety of other motor system disorders and other neurologic disorders. Fluorescein conjugated goat antihuman IgG and IgM monospecific immunoglobulins were used to characterize further the cytotoxic activity from patient sera and these studies suggested the presence of immunoglobulin G (IgG) and immunoglobulin M (IgM) directed against a cell surface neuroblastoma antigen. Cold reactive immunoglobulins of the IgG and IgM type were present in the sera of all 6 patients. A bioassay is described that may be helpful in evaluating other patients with progressive idiopathic polyneuropathies.

AB - Sera from 6 patients with progressive idiopathic acute or chronic polyneuropathy possessed a cytolytic activity against transformed mouse cholinergic or noncholinergic neuroblasts but not against transformed rat astrocytes. This activity was not qualitatively present in sera from normal controls or from patients with a variety of other motor system disorders and other neurologic disorders. Fluorescein conjugated goat antihuman IgG and IgM monospecific immunoglobulins were used to characterize further the cytotoxic activity from patient sera and these studies suggested the presence of immunoglobulin G (IgG) and immunoglobulin M (IgM) directed against a cell surface neuroblastoma antigen. Cold reactive immunoglobulins of the IgG and IgM type were present in the sera of all 6 patients. A bioassay is described that may be helpful in evaluating other patients with progressive idiopathic polyneuropathies.

UR - http://www.scopus.com/inward/record.url?scp=0016620252&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016620252&partnerID=8YFLogxK

M3 - Article

C2 - 1238954

AN - SCOPUS:0016620252

VL - 25

SP - 1101

EP - 1110

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 12

ER -