TY - JOUR
T1 - IgA multiple myeloma presenting AS Henoch-Schönlein purpura/polyarteritis nodosa overlap syndrome
AU - Birchmore, Daniel
AU - Sweeney, Christine
AU - Choudhury, Devasmita
AU - Konwinski, Martin F.
AU - Carnevale, Kevin
AU - D'Agati, Vivette
PY - 1996/4
Y1 - 1996/4
N2 - We report the unusual case of a man with a 5-year history of relapsing Henoch-Schönlein purpura (HSP) and macroscopic polyarteritis nodosa (PAN) as early manifestations of IgAκ multiple myeloma. The glomeruli contained monoclonal IgAκ deposits, without other immunoglobulins or λ light chains. Glomerular deposits lacked the usual electron density but could be demonstrated by immunoelectron microscopy. Multisystem large vessel vasculitis (antineutrophil cytoplasmic antibody negative) produced aneurysms of renal and hepatic arteries, whereas small vessel vasculitis affected the skin and glomeruli, producing a symptom complex of HSP with dermal and glomerular deposits of IgA. We conclude that HSP/overlap syndrome may be the initial manifestation of IgA myeloma and should be considered within the spectrum of monoclonal IgA deposition disease.
AB - We report the unusual case of a man with a 5-year history of relapsing Henoch-Schönlein purpura (HSP) and macroscopic polyarteritis nodosa (PAN) as early manifestations of IgAκ multiple myeloma. The glomeruli contained monoclonal IgAκ deposits, without other immunoglobulins or λ light chains. Glomerular deposits lacked the usual electron density but could be demonstrated by immunoelectron microscopy. Multisystem large vessel vasculitis (antineutrophil cytoplasmic antibody negative) produced aneurysms of renal and hepatic arteries, whereas small vessel vasculitis affected the skin and glomeruli, producing a symptom complex of HSP with dermal and glomerular deposits of IgA. We conclude that HSP/overlap syndrome may be the initial manifestation of IgA myeloma and should be considered within the spectrum of monoclonal IgA deposition disease.
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U2 - 10.1002/art.1780390425
DO - 10.1002/art.1780390425
M3 - Article
C2 - 8630124
AN - SCOPUS:0029873372
SN - 0004-3591
VL - 39
SP - 698
EP - 703
JO - Arthritis and rheumatism
JF - Arthritis and rheumatism
IS - 4
ER -