Imaging of post-mortem human brain tissue using electron and X-ray microscopy

Amanda J. Lewis, Christel Genoud, Mélissa Pont, Wilma DJ van de Berg, Stephan Frank, Henning Stahlberg, Sarah H. Shahmoradian, Ashraf Al-Amoudi

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Electron microscopy imaging of post-mortem human brain (PMHB) comes with a unique set of challenges due to numerous parameters beyond the researcher's control. Nevertheless, the wealth of information provided by the ultrastructural analysis of PMHB is proving crucial in our understanding of neurodegenerative diseases. This review highlights the importance of such studies and covers challenges, limitations and recent developments in the application of current EM imaging, including cryo-ET and correlative hybrid techniques, on PMHB.

Original languageEnglish (US)
Pages (from-to)138-148
Number of pages11
JournalCurrent Opinion in Structural Biology
Volume58
DOIs
StatePublished - Oct 2019
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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