Imaging the coordination of multiple signalling activities in living cells

Christopher M. Welch, Hunter Elliott, Gaudenz Danuser, Klaus M. Hahn

Research output: Contribution to journalReview article

101 Scopus citations

Abstract

Cellular signal transduction occurs in complex and redundant interaction networks, which are best understood by simultaneously monitoring the activation dynamics of multiple components. Recent advances in biosensor technology have made it possible to visualize and quantify the activation of multiple network nodes in the same living cell. The precision and scope of this approach has been greatly extended by novel computational approaches (referred to as computational multiplexing) that can reveal relationships between network nodes imaged in separate cells.

Original languageEnglish (US)
Pages (from-to)749-756
Number of pages8
JournalNature Reviews Molecular Cell Biology
Volume12
Issue number11
DOIs
StatePublished - Nov 1 2011

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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