Abstract
Cellular signal transduction occurs in complex and redundant interaction networks, which are best understood by simultaneously monitoring the activation dynamics of multiple components. Recent advances in biosensor technology have made it possible to visualize and quantify the activation of multiple network nodes in the same living cell. The precision and scope of this approach has been greatly extended by novel computational approaches (referred to as computational multiplexing) that can reveal relationships between network nodes imaged in separate cells.
Original language | English (US) |
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Pages (from-to) | 749-756 |
Number of pages | 8 |
Journal | Nature Reviews Molecular Cell Biology |
Volume | 12 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2011 |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology