Estudio inmunohistoquimico de bcl-2 y MIB-1/KI-67 en el carcinoma de mama analisis retrospectivo en 238 casos

Translated title of the contribution: Immunohistochemical detection of bcl-2 and MIB-1/Ki-67 in breast cancer. Retrospective analysis of 238 cases

Alberto S. Sundblad, Chul Ahn, Hector Battifora

Research output: Contribution to journalArticle

7 Scopus citations


We considered of interest to determine the possible interrelationship between the proliferation-related marker MIB-1/Ki-67 and the bcl-2, a protein involved in the blockage of apoptosis, and whether they contributed to the prognosis of breast cancer. For this purpose we carried out a retrospective immunohistochemical study of 238 cases of stage I and II breast carcinomas with a follow up of at least 5 years. The study revealed that high expression of MIB-1 was associated with high nuclear and histological grades (p < 0,001 for both), negative estrogen receptor status (p = 0.009) and progesterone status (p = 0.004), and younger age (p = 0.014). High bcl-2 expression was associated with smaller tumor size (p = 0.001); positive estrogen and progesterone receptors (p< 0.001 for both); low nuclear grade (p < 0.001), low histological grade (p < 0.002), stage I disease (p = 0.01) and low MIB-1 expression (p = 0.025). The univariate Cox regression showed a significant association of high MIB-1 expression (p = 0.002) and low bcl-2 expression (p = 0.04) with shorter OS. Furthermore, MIB-1 expression was a significant independent predictor of OS (p = 0.002) as showed by stepwise Cox regression analysis.

Original languageSpanish
Pages (from-to)252-258
Number of pages7
Issue number3
StatePublished - Dec 1 1996


ASJC Scopus subject areas

  • Medicine(all)

Cite this