Abstract
Mammalian Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens by dendritic cells (DCs). Although TLRs are clearly involved in the detection of bacteria and viruses, relatively little is known about their function in the innate response to eukaryotic microorganisms. Here we identify a profilin-like molecule from the protozoan parasite Toxoplasma gondii that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88. T. gondii profilin activates DCs through TLR11 and is the first chemically defined ligand for this TLR. Moreover, TLR11 is required in vivo for parasite-induced IL-12 production and optimal resistance to infection, thereby establishing a role for the receptor in host recognition of protozoan pathogens.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1626-1629 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 308 |
| Issue number | 5728 |
| DOIs | |
| State | Published - Jun 10 2005 |
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Cite this
Immunology : TLR11 activation of dendritic cells by a protozoan profilin-like protein. / Yarovinsky, Felix; Zhang, Dekai; Andersen, John F.; Bannenberg, Gerard L.; Serhan, Charles N.; Hayden, Matthew S.; Hieny, Sara; Sutterwala, Fayyaz S.; Flavell, Richard A.; Ghosh, Sankar; Sher, Alan.
In: Science, Vol. 308, No. 5728, 10.06.2005, p. 1626-1629.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunology
T2 - TLR11 activation of dendritic cells by a protozoan profilin-like protein
AU - Yarovinsky, Felix
AU - Zhang, Dekai
AU - Andersen, John F.
AU - Bannenberg, Gerard L.
AU - Serhan, Charles N.
AU - Hayden, Matthew S.
AU - Hieny, Sara
AU - Sutterwala, Fayyaz S.
AU - Flavell, Richard A.
AU - Ghosh, Sankar
AU - Sher, Alan
PY - 2005/6/10
Y1 - 2005/6/10
N2 - Mammalian Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens by dendritic cells (DCs). Although TLRs are clearly involved in the detection of bacteria and viruses, relatively little is known about their function in the innate response to eukaryotic microorganisms. Here we identify a profilin-like molecule from the protozoan parasite Toxoplasma gondii that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88. T. gondii profilin activates DCs through TLR11 and is the first chemically defined ligand for this TLR. Moreover, TLR11 is required in vivo for parasite-induced IL-12 production and optimal resistance to infection, thereby establishing a role for the receptor in host recognition of protozoan pathogens.
AB - Mammalian Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens by dendritic cells (DCs). Although TLRs are clearly involved in the detection of bacteria and viruses, relatively little is known about their function in the innate response to eukaryotic microorganisms. Here we identify a profilin-like molecule from the protozoan parasite Toxoplasma gondii that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88. T. gondii profilin activates DCs through TLR11 and is the first chemically defined ligand for this TLR. Moreover, TLR11 is required in vivo for parasite-induced IL-12 production and optimal resistance to infection, thereby establishing a role for the receptor in host recognition of protozoan pathogens.
UR - http://www.scopus.com/inward/record.url?scp=20644433342&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20644433342&partnerID=8YFLogxK
U2 - 10.1126/science.1109893
DO - 10.1126/science.1109893
M3 - Article
C2 - 15860593
AN - SCOPUS:20644433342
VL - 308
SP - 1626
EP - 1629
JO - Science
JF - Science
SN - 0036-8075
IS - 5728
ER -