Immunology: TLR11 activation of dendritic cells by a protozoan profilin-like protein

Felix Yarovinsky; Dekai Zhang; John F. Andersen; Gerard L. Bannenberg; Charles N. Serhan; Matthew S. Hayden; Sara Hieny; Fayyaz S. Sutterwala; Richard A. Flavell; Sankar Ghosh; Alan Sher

doi:10.1126/science.1109893

Immunology: TLR11 activation of dendritic cells by a protozoan profilin-like protein

Felix Yarovinsky, Dekai Zhang, John F. Andersen, Gerard L. Bannenberg, Charles N. Serhan, Matthew S. Hayden, Sara Hieny, Fayyaz S. Sutterwala, Richard A. Flavell, Sankar Ghosh, Alan Sher

Immunology

Research output: Contribution to journal › Article › peer-review

737 Scopus citations

Abstract

Mammalian Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens by dendritic cells (DCs). Although TLRs are clearly involved in the detection of bacteria and viruses, relatively little is known about their function in the innate response to eukaryotic microorganisms. Here we identify a profilin-like molecule from the protozoan parasite Toxoplasma gondii that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88. T. gondii profilin activates DCs through TLR11 and is the first chemically defined ligand for this TLR. Moreover, TLR11 is required in vivo for parasite-induced IL-12 production and optimal resistance to infection, thereby establishing a role for the receptor in host recognition of protozoan pathogens.

Original language	English (US)
Pages (from-to)	1626-1629
Number of pages	4
Journal	Science
Volume	308
Issue number	5728
DOIs	https://doi.org/10.1126/science.1109893
State	Published - Jun 10 2005

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Immunology : TLR11 activation of dendritic cells by a protozoan profilin-like protein. / Yarovinsky, Felix; Zhang, Dekai; Andersen, John F.; Bannenberg, Gerard L.; Serhan, Charles N.; Hayden, Matthew S.; Hieny, Sara; Sutterwala, Fayyaz S.; Flavell, Richard A.; Ghosh, Sankar; Sher, Alan.

In: Science, Vol. 308, No. 5728, 10.06.2005, p. 1626-1629.

Research output: Contribution to journal › Article › peer-review

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abstract = "Mammalian Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens by dendritic cells (DCs). Although TLRs are clearly involved in the detection of bacteria and viruses, relatively little is known about their function in the innate response to eukaryotic microorganisms. Here we identify a profilin-like molecule from the protozoan parasite Toxoplasma gondii that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88. T. gondii profilin activates DCs through TLR11 and is the first chemically defined ligand for this TLR. Moreover, TLR11 is required in vivo for parasite-induced IL-12 production and optimal resistance to infection, thereby establishing a role for the receptor in host recognition of protozoan pathogens.",

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AU - Yarovinsky, Felix

AU - Zhang, Dekai

AU - Andersen, John F.

AU - Bannenberg, Gerard L.

AU - Serhan, Charles N.

AU - Hayden, Matthew S.

AU - Hieny, Sara

AU - Sutterwala, Fayyaz S.

AU - Flavell, Richard A.

AU - Ghosh, Sankar

AU - Sher, Alan

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AB - Mammalian Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens by dendritic cells (DCs). Although TLRs are clearly involved in the detection of bacteria and viruses, relatively little is known about their function in the innate response to eukaryotic microorganisms. Here we identify a profilin-like molecule from the protozoan parasite Toxoplasma gondii that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88. T. gondii profilin activates DCs through TLR11 and is the first chemically defined ligand for this TLR. Moreover, TLR11 is required in vivo for parasite-induced IL-12 production and optimal resistance to infection, thereby establishing a role for the receptor in host recognition of protozoan pathogens.

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Immunology: TLR11 activation of dendritic cells by a protozoan profilin-like protein

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