Immunomodulatory and therapeutic activity of curcumin

Raghvendra M. Srivastava, Sarvjeet Singh, Shiv K. Dubey, Krishna Misra, Ashok Khar

Research output: Contribution to journalReview article

138 Scopus citations

Abstract

Inflammation is a disease of vigorous uncontrolled activated immune responses. Overwhelming reports have suggested that the modulation of immune responses by curcumin plays a dominant role in the treatment of inflammation and metabolic diseases. Observations from both in-vitro and in-vivo studies have provided strong evidence towards the therapeutic potential of curcumin. These studies have also identified a plethora of biological targets and intricate mechanisms of action that characterize curcumin as a potent 'drug' for numerous ailments. During inflammation the functional influence of lymphocytes and the related cross-talk can be modulated by curcumin to achieve the desired immune status against diseases. This review describes the regulation of immune responses by curcumin and effectiveness of curcumin in treatment of diseases of diverse nature.

Original languageEnglish (US)
Pages (from-to)331-341
Number of pages11
JournalInternational Immunopharmacology
Volume11
Issue number3
DOIs
StatePublished - Mar 1 2011

Keywords

  • Anti-cancerous
  • Anti-inflammatory
  • Curcumin
  • Immune and metabolic diseases

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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    Srivastava, R. M., Singh, S., Dubey, S. K., Misra, K., & Khar, A. (2011). Immunomodulatory and therapeutic activity of curcumin. International Immunopharmacology, 11(3), 331-341. https://doi.org/10.1016/j.intimp.2010.08.014