Immunoregulation of retinal ganglion cell fate in glaucoma

Martin B. Wax, Gülgün Tezel

Research output: Contribution to journalReview article

95 Scopus citations

Abstract

Glaucomatous neurodegeneration has been associated with the activation of multiple pathogenic mechanisms that can result in RGC death and axonal degeneration. Growing evidence obtained from clinical and experimental studies over the last decade also strongly suggests the involvement of the immune system in the neurodegenerative process of glaucoma. The roles of the immune system in glaucoma have been described as either neuroprotective or neurodestructive. It has been proposed that a critical balance between beneficial protective immunity and harmful sequelae of autoimmune neurodegenerative injury determines the ultimate fate of RGCs in response to various stressors in patients with glaucoma. Here, we review the key role for immunoregulation in cell fate decisions regarding RGC survival in response to glaucomatous tissue stress. Furthermore, we review the mechanisms by which autoimmunity to specific antigens such as heat shock proteins may result in RGC demise in some patients with glaucoma. In these patients, we hypothesized that one form of glaucoma may be an autoimmune optic neuropathy in which an individual's immune system facilitates a somatic or axonal degeneration of RGCs by the very system which normally serves to protect it against stress.

Original languageEnglish (US)
Pages (from-to)825-830
Number of pages6
JournalExperimental Eye Research
Volume88
Issue number4
DOIs
StatePublished - Apr 30 2009

Keywords

  • autoimmunity
  • glaucoma
  • heat shock proteins
  • immunology
  • immunoregulation of RGC fate
  • retinal ganglion cell

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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