Immunotherapy for allergic fungal sinusitis: Three years' experience

R. L. Mabry, B. F. Marple, R. J. Folker, C. S. Mabry

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Since August 1994, we have treated patients with histologically proven allergic fungal sinusitis with surgery followed by immunotherapy, employing fungal and nonfungal antigens to which hypersensitivity has been demonstrated. Our results continue to be encouraging. Not only have we encountered no indication that fungal immunotherapy has worsened these patients' condition or caused a recurrence of disease, we have confirmed dramatic improvement in these patients compared with the generally accepted course of this disease. Of 11 patients who have received immunotherapy for 1 to 3 years (mean 28 months), none has required regular or frequent treatment with a single brief course of systemic steroids, and only three are receiving topical nasal steroids. No repeat surgeries for recurrent allergic fungal sinusitis have been required in the treatment group. This combination of surgery and immunotherapy has continued to prove beneficial, and we urge others to consider this approach to therapy.

Original languageEnglish (US)
Pages (from-to)648-651
Number of pages4
JournalOtolaryngology - Head and Neck Surgery
Volume119
Issue number6
DOIs
StatePublished - 1998

Fingerprint

Sinusitis
Immunotherapy
Fungal Antigens
Steroids
Reoperation
Nose
Hypersensitivity
Therapeutics
Recurrence

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Immunotherapy for allergic fungal sinusitis : Three years' experience. / Mabry, R. L.; Marple, B. F.; Folker, R. J.; Mabry, C. S.

In: Otolaryngology - Head and Neck Surgery, Vol. 119, No. 6, 1998, p. 648-651.

Research output: Contribution to journalArticle

Mabry, R. L. ; Marple, B. F. ; Folker, R. J. ; Mabry, C. S. / Immunotherapy for allergic fungal sinusitis : Three years' experience. In: Otolaryngology - Head and Neck Surgery. 1998 ; Vol. 119, No. 6. pp. 648-651.
@article{2d18ab24944a45e79e3ec873cc204788,
title = "Immunotherapy for allergic fungal sinusitis: Three years' experience",
abstract = "Since August 1994, we have treated patients with histologically proven allergic fungal sinusitis with surgery followed by immunotherapy, employing fungal and nonfungal antigens to which hypersensitivity has been demonstrated. Our results continue to be encouraging. Not only have we encountered no indication that fungal immunotherapy has worsened these patients' condition or caused a recurrence of disease, we have confirmed dramatic improvement in these patients compared with the generally accepted course of this disease. Of 11 patients who have received immunotherapy for 1 to 3 years (mean 28 months), none has required regular or frequent treatment with a single brief course of systemic steroids, and only three are receiving topical nasal steroids. No repeat surgeries for recurrent allergic fungal sinusitis have been required in the treatment group. This combination of surgery and immunotherapy has continued to prove beneficial, and we urge others to consider this approach to therapy.",
author = "Mabry, {R. L.} and Marple, {B. F.} and Folker, {R. J.} and Mabry, {C. S.}",
year = "1998",
doi = "10.1016/S0194-5998(98)70027-0",
language = "English (US)",
volume = "119",
pages = "648--651",
journal = "Otolaryngology - Head and Neck Surgery (United States)",
issn = "0194-5998",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Immunotherapy for allergic fungal sinusitis

T2 - Three years' experience

AU - Mabry, R. L.

AU - Marple, B. F.

AU - Folker, R. J.

AU - Mabry, C. S.

PY - 1998

Y1 - 1998

N2 - Since August 1994, we have treated patients with histologically proven allergic fungal sinusitis with surgery followed by immunotherapy, employing fungal and nonfungal antigens to which hypersensitivity has been demonstrated. Our results continue to be encouraging. Not only have we encountered no indication that fungal immunotherapy has worsened these patients' condition or caused a recurrence of disease, we have confirmed dramatic improvement in these patients compared with the generally accepted course of this disease. Of 11 patients who have received immunotherapy for 1 to 3 years (mean 28 months), none has required regular or frequent treatment with a single brief course of systemic steroids, and only three are receiving topical nasal steroids. No repeat surgeries for recurrent allergic fungal sinusitis have been required in the treatment group. This combination of surgery and immunotherapy has continued to prove beneficial, and we urge others to consider this approach to therapy.

AB - Since August 1994, we have treated patients with histologically proven allergic fungal sinusitis with surgery followed by immunotherapy, employing fungal and nonfungal antigens to which hypersensitivity has been demonstrated. Our results continue to be encouraging. Not only have we encountered no indication that fungal immunotherapy has worsened these patients' condition or caused a recurrence of disease, we have confirmed dramatic improvement in these patients compared with the generally accepted course of this disease. Of 11 patients who have received immunotherapy for 1 to 3 years (mean 28 months), none has required regular or frequent treatment with a single brief course of systemic steroids, and only three are receiving topical nasal steroids. No repeat surgeries for recurrent allergic fungal sinusitis have been required in the treatment group. This combination of surgery and immunotherapy has continued to prove beneficial, and we urge others to consider this approach to therapy.

UR - http://www.scopus.com/inward/record.url?scp=0032439124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032439124&partnerID=8YFLogxK

U2 - 10.1016/S0194-5998(98)70027-0

DO - 10.1016/S0194-5998(98)70027-0

M3 - Article

C2 - 9852541

AN - SCOPUS:0032439124

VL - 119

SP - 648

EP - 651

JO - Otolaryngology - Head and Neck Surgery (United States)

JF - Otolaryngology - Head and Neck Surgery (United States)

SN - 0194-5998

IS - 6

ER -