Abstract
Partially deglycosylated (dg) ricin A and B chains were coupled to rabbit anti-human Ig (IT-dg-A) and goat anti-rabbit Ig (IT-dg-B), respectively. The deglycosylation was accomplished by treating intact ricin (before separation into its constituent chains) with a mixture of sodium metaperiodate and sodium cyanobrohydride. The two immunotoxins (ITs) acted synergistically in vitro to kill Daudi cells, albeit to a four-to-eight-fold lesser degree than ITs prepared with native A and B chains.
Original language | English (US) |
---|---|
Pages (from-to) | 191-198 |
Number of pages | 8 |
Journal | Cancer Drug Delivery |
Volume | 2 |
Issue number | 3 |
DOIs | |
State | Published - 1985 |
ASJC Scopus subject areas
- Pharmacology
- Cancer Research