Immunotoxins in the therapy of cancer: From bench to clinic

Victor Ghetie, Ellen Vitetta

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

This review presents only those contributions that have progressed from the bench to the clinic using murine monoclonal antibodies coupled chemically to toxins, their subunits or ribosome-inactivating proteins. The rationale and progress in the development, characterization, preclinical testing and clinical trials are discussed.

Original languageEnglish (US)
Pages (from-to)209-234
Number of pages26
JournalPharmacology and Therapeutics
Volume63
Issue number3
DOIs
StatePublished - 1994

Keywords

  • Immunotoxin
  • cancer
  • monoclonal antibody
  • therapy

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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