Impact of diabetes mellitus on acute outcomes of percutaneous coronary intervention in chronic total occlusions

Insights from a US multicentre registry

J. R. Martinez-Parachini, A. Karatasakis, D. Karmpaliotis, K. Alaswad, F. A. Jaffer, R. W. Yeh, M. Patel, J. Bahadorani, A. Doing, P. K. Nguyen-Trong, B. A. Danek, J. Karacsonyi, A. Alame, B. V. Rangan, C. A. Thompson, S. Banerjee, E. S. Brilakis

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aim: To examine the impact of diabetes mellitus on procedural outcomes of patients who underwent percutaneous coronary intervention for chronic total occlusion. Methods: We assessed the impact of diabetes mellitus on the outcomes of percutaneous coronary intervention for chronic total occlusion among 1308 people who underwent such procedures at 11 US centres between 2012 and 2015. Results: The participants' mean ± sd age was 66 ± 10 years, 84% of the participants were men and 44.6% had diabetes. As compared with participants without diabetes, participants with diabetes were more likely to have undergone coronary artery bypass graft surgery (38 vs 31%; P = 0.006), and to have had previous heart failure (35 vs 22%; P = 0.0001) and peripheral arterial disease (19 vs 13%; P = 0.002). They also had a higher BMI (31 ± 6 kg/m2 vs 29 ± 6 kg/m2; P = 0.001), similar Japanese chronic total occlusion scores (2.6 ± 1.2 vs 2.5 ± 1.2; P = 0.82) and similar final successful crossing technique: antegrade wire escalation (46 vs 47%; P = 0.66), retrograde (30 vs 28%; P = 0.66) and antegrade dissection re-entry (24 vs 25%; P = 0.66). Technical (91 vs 90%; P = 0.80) and procedural (89 vs 89%; P = 0.93) success was similar in the two groups, as was the incidence of major adverse cardiac events (2.2 vs 2.5%; P = 0.61). Conclusions: In a contemporary cohort of people undergoing percutaneous coronary intervention for chronic total occlusion, nearly one in two (45%) had diabetes mellitus. Procedural success and complication rates were similar in people with and without diabetes.

Original languageEnglish (US)
JournalDiabetic Medicine
DOIs
StateAccepted/In press - 2016

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Percutaneous Coronary Intervention
Registries
Diabetes Mellitus
Peripheral Arterial Disease
Coronary Artery Bypass
Dissection
Heart Failure
Transplants
Incidence

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Impact of diabetes mellitus on acute outcomes of percutaneous coronary intervention in chronic total occlusions : Insights from a US multicentre registry. / Martinez-Parachini, J. R.; Karatasakis, A.; Karmpaliotis, D.; Alaswad, K.; Jaffer, F. A.; Yeh, R. W.; Patel, M.; Bahadorani, J.; Doing, A.; Nguyen-Trong, P. K.; Danek, B. A.; Karacsonyi, J.; Alame, A.; Rangan, B. V.; Thompson, C. A.; Banerjee, S.; Brilakis, E. S.

In: Diabetic Medicine, 2016.

Research output: Contribution to journalArticle

Martinez-Parachini, JR, Karatasakis, A, Karmpaliotis, D, Alaswad, K, Jaffer, FA, Yeh, RW, Patel, M, Bahadorani, J, Doing, A, Nguyen-Trong, PK, Danek, BA, Karacsonyi, J, Alame, A, Rangan, BV, Thompson, CA, Banerjee, S & Brilakis, ES 2016, 'Impact of diabetes mellitus on acute outcomes of percutaneous coronary intervention in chronic total occlusions: Insights from a US multicentre registry', Diabetic Medicine. https://doi.org/10.1111/dme.13272
Martinez-Parachini, J. R. ; Karatasakis, A. ; Karmpaliotis, D. ; Alaswad, K. ; Jaffer, F. A. ; Yeh, R. W. ; Patel, M. ; Bahadorani, J. ; Doing, A. ; Nguyen-Trong, P. K. ; Danek, B. A. ; Karacsonyi, J. ; Alame, A. ; Rangan, B. V. ; Thompson, C. A. ; Banerjee, S. ; Brilakis, E. S. / Impact of diabetes mellitus on acute outcomes of percutaneous coronary intervention in chronic total occlusions : Insights from a US multicentre registry. In: Diabetic Medicine. 2016.
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abstract = "Aim: To examine the impact of diabetes mellitus on procedural outcomes of patients who underwent percutaneous coronary intervention for chronic total occlusion. Methods: We assessed the impact of diabetes mellitus on the outcomes of percutaneous coronary intervention for chronic total occlusion among 1308 people who underwent such procedures at 11 US centres between 2012 and 2015. Results: The participants' mean ± sd age was 66 ± 10 years, 84{\%} of the participants were men and 44.6{\%} had diabetes. As compared with participants without diabetes, participants with diabetes were more likely to have undergone coronary artery bypass graft surgery (38 vs 31{\%}; P = 0.006), and to have had previous heart failure (35 vs 22{\%}; P = 0.0001) and peripheral arterial disease (19 vs 13{\%}; P = 0.002). They also had a higher BMI (31 ± 6 kg/m2 vs 29 ± 6 kg/m2; P = 0.001), similar Japanese chronic total occlusion scores (2.6 ± 1.2 vs 2.5 ± 1.2; P = 0.82) and similar final successful crossing technique: antegrade wire escalation (46 vs 47{\%}; P = 0.66), retrograde (30 vs 28{\%}; P = 0.66) and antegrade dissection re-entry (24 vs 25{\%}; P = 0.66). Technical (91 vs 90{\%}; P = 0.80) and procedural (89 vs 89{\%}; P = 0.93) success was similar in the two groups, as was the incidence of major adverse cardiac events (2.2 vs 2.5{\%}; P = 0.61). Conclusions: In a contemporary cohort of people undergoing percutaneous coronary intervention for chronic total occlusion, nearly one in two (45{\%}) had diabetes mellitus. Procedural success and complication rates were similar in people with and without diabetes.",
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T1 - Impact of diabetes mellitus on acute outcomes of percutaneous coronary intervention in chronic total occlusions

T2 - Insights from a US multicentre registry

AU - Martinez-Parachini, J. R.

AU - Karatasakis, A.

AU - Karmpaliotis, D.

AU - Alaswad, K.

AU - Jaffer, F. A.

AU - Yeh, R. W.

AU - Patel, M.

AU - Bahadorani, J.

AU - Doing, A.

AU - Nguyen-Trong, P. K.

AU - Danek, B. A.

AU - Karacsonyi, J.

AU - Alame, A.

AU - Rangan, B. V.

AU - Thompson, C. A.

AU - Banerjee, S.

AU - Brilakis, E. S.

PY - 2016

Y1 - 2016

N2 - Aim: To examine the impact of diabetes mellitus on procedural outcomes of patients who underwent percutaneous coronary intervention for chronic total occlusion. Methods: We assessed the impact of diabetes mellitus on the outcomes of percutaneous coronary intervention for chronic total occlusion among 1308 people who underwent such procedures at 11 US centres between 2012 and 2015. Results: The participants' mean ± sd age was 66 ± 10 years, 84% of the participants were men and 44.6% had diabetes. As compared with participants without diabetes, participants with diabetes were more likely to have undergone coronary artery bypass graft surgery (38 vs 31%; P = 0.006), and to have had previous heart failure (35 vs 22%; P = 0.0001) and peripheral arterial disease (19 vs 13%; P = 0.002). They also had a higher BMI (31 ± 6 kg/m2 vs 29 ± 6 kg/m2; P = 0.001), similar Japanese chronic total occlusion scores (2.6 ± 1.2 vs 2.5 ± 1.2; P = 0.82) and similar final successful crossing technique: antegrade wire escalation (46 vs 47%; P = 0.66), retrograde (30 vs 28%; P = 0.66) and antegrade dissection re-entry (24 vs 25%; P = 0.66). Technical (91 vs 90%; P = 0.80) and procedural (89 vs 89%; P = 0.93) success was similar in the two groups, as was the incidence of major adverse cardiac events (2.2 vs 2.5%; P = 0.61). Conclusions: In a contemporary cohort of people undergoing percutaneous coronary intervention for chronic total occlusion, nearly one in two (45%) had diabetes mellitus. Procedural success and complication rates were similar in people with and without diabetes.

AB - Aim: To examine the impact of diabetes mellitus on procedural outcomes of patients who underwent percutaneous coronary intervention for chronic total occlusion. Methods: We assessed the impact of diabetes mellitus on the outcomes of percutaneous coronary intervention for chronic total occlusion among 1308 people who underwent such procedures at 11 US centres between 2012 and 2015. Results: The participants' mean ± sd age was 66 ± 10 years, 84% of the participants were men and 44.6% had diabetes. As compared with participants without diabetes, participants with diabetes were more likely to have undergone coronary artery bypass graft surgery (38 vs 31%; P = 0.006), and to have had previous heart failure (35 vs 22%; P = 0.0001) and peripheral arterial disease (19 vs 13%; P = 0.002). They also had a higher BMI (31 ± 6 kg/m2 vs 29 ± 6 kg/m2; P = 0.001), similar Japanese chronic total occlusion scores (2.6 ± 1.2 vs 2.5 ± 1.2; P = 0.82) and similar final successful crossing technique: antegrade wire escalation (46 vs 47%; P = 0.66), retrograde (30 vs 28%; P = 0.66) and antegrade dissection re-entry (24 vs 25%; P = 0.66). Technical (91 vs 90%; P = 0.80) and procedural (89 vs 89%; P = 0.93) success was similar in the two groups, as was the incidence of major adverse cardiac events (2.2 vs 2.5%; P = 0.61). Conclusions: In a contemporary cohort of people undergoing percutaneous coronary intervention for chronic total occlusion, nearly one in two (45%) had diabetes mellitus. Procedural success and complication rates were similar in people with and without diabetes.

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