Impact of diabetes mellitus on the outcome of pancreatic cancer

Muhammad Shaalan Beg, Alok Kumar Dwivedi, Syed Arif Ahmad, Sadia Ali, Olugbenga Olowokure

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Introduction: Diabetes mellitus (DM) has the potential to impact the pathogenesis, treatment, and outcome of pancreatic cancer. This study evaluates the impact of DM on pancreatic cancer survival. Methods: We conducted a retrospective cohort study from the Veterans Affairs (VA) Central Cancer Registry (VACCR) for pancreatic cancer cases between 1995 and 2008. DM and no-DM cases were identified from comorbidity data. Univariate and multivariable analysis was performed. Multiple imputation method was employed to account for missing variables. Results: Of 8,466 cases of pancreatic cancer DM status was known in 4728 cases that comprised this analysis. Males accounted for 97.7% cases, and 78% were white. Overall survival was 4.2 months in DM group and 3.6 months in the no-DM group. In multivariable analysis, DM had a HR = 0.91 (0.849-0.974). This finding persisted after accounting for missing variables using multiple imputations method with the HR in DM group of 0.93 (0.867-0.997). Conclusions: Our data suggest DM is associated with a reduction in risk of death in pancreatic cancer. Future studies should be directed towards examining this association, specifically impact of DM medications on cancer outcome.

Original languageEnglish (US)
Article numbere98511
JournalPLoS One
Volume9
Issue number5
DOIs
StatePublished - May 30 2014

Fingerprint

pancreatic neoplasms
Medical problems
diabetes mellitus
Pancreatic Neoplasms
Diabetes Mellitus
veterans
neoplasms
Survival
risk reduction
Veterans
Risk Reduction Behavior
cohort studies
drug therapy
Registries
Comorbidity
Neoplasms
Cohort Studies
pathogenesis
Retrospective Studies
methodology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Impact of diabetes mellitus on the outcome of pancreatic cancer. / Beg, Muhammad Shaalan; Dwivedi, Alok Kumar; Ahmad, Syed Arif; Ali, Sadia; Olowokure, Olugbenga.

In: PLoS One, Vol. 9, No. 5, e98511, 30.05.2014.

Research output: Contribution to journalArticle

Beg, Muhammad Shaalan ; Dwivedi, Alok Kumar ; Ahmad, Syed Arif ; Ali, Sadia ; Olowokure, Olugbenga. / Impact of diabetes mellitus on the outcome of pancreatic cancer. In: PLoS One. 2014 ; Vol. 9, No. 5.
@article{49fc7cca5681421b9422b09d8ee53a08,
title = "Impact of diabetes mellitus on the outcome of pancreatic cancer",
abstract = "Introduction: Diabetes mellitus (DM) has the potential to impact the pathogenesis, treatment, and outcome of pancreatic cancer. This study evaluates the impact of DM on pancreatic cancer survival. Methods: We conducted a retrospective cohort study from the Veterans Affairs (VA) Central Cancer Registry (VACCR) for pancreatic cancer cases between 1995 and 2008. DM and no-DM cases were identified from comorbidity data. Univariate and multivariable analysis was performed. Multiple imputation method was employed to account for missing variables. Results: Of 8,466 cases of pancreatic cancer DM status was known in 4728 cases that comprised this analysis. Males accounted for 97.7{\%} cases, and 78{\%} were white. Overall survival was 4.2 months in DM group and 3.6 months in the no-DM group. In multivariable analysis, DM had a HR = 0.91 (0.849-0.974). This finding persisted after accounting for missing variables using multiple imputations method with the HR in DM group of 0.93 (0.867-0.997). Conclusions: Our data suggest DM is associated with a reduction in risk of death in pancreatic cancer. Future studies should be directed towards examining this association, specifically impact of DM medications on cancer outcome.",
author = "Beg, {Muhammad Shaalan} and Dwivedi, {Alok Kumar} and Ahmad, {Syed Arif} and Sadia Ali and Olugbenga Olowokure",
year = "2014",
month = "5",
day = "30",
doi = "10.1371/journal.pone.0098511",
language = "English (US)",
volume = "9",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

TY - JOUR

T1 - Impact of diabetes mellitus on the outcome of pancreatic cancer

AU - Beg, Muhammad Shaalan

AU - Dwivedi, Alok Kumar

AU - Ahmad, Syed Arif

AU - Ali, Sadia

AU - Olowokure, Olugbenga

PY - 2014/5/30

Y1 - 2014/5/30

N2 - Introduction: Diabetes mellitus (DM) has the potential to impact the pathogenesis, treatment, and outcome of pancreatic cancer. This study evaluates the impact of DM on pancreatic cancer survival. Methods: We conducted a retrospective cohort study from the Veterans Affairs (VA) Central Cancer Registry (VACCR) for pancreatic cancer cases between 1995 and 2008. DM and no-DM cases were identified from comorbidity data. Univariate and multivariable analysis was performed. Multiple imputation method was employed to account for missing variables. Results: Of 8,466 cases of pancreatic cancer DM status was known in 4728 cases that comprised this analysis. Males accounted for 97.7% cases, and 78% were white. Overall survival was 4.2 months in DM group and 3.6 months in the no-DM group. In multivariable analysis, DM had a HR = 0.91 (0.849-0.974). This finding persisted after accounting for missing variables using multiple imputations method with the HR in DM group of 0.93 (0.867-0.997). Conclusions: Our data suggest DM is associated with a reduction in risk of death in pancreatic cancer. Future studies should be directed towards examining this association, specifically impact of DM medications on cancer outcome.

AB - Introduction: Diabetes mellitus (DM) has the potential to impact the pathogenesis, treatment, and outcome of pancreatic cancer. This study evaluates the impact of DM on pancreatic cancer survival. Methods: We conducted a retrospective cohort study from the Veterans Affairs (VA) Central Cancer Registry (VACCR) for pancreatic cancer cases between 1995 and 2008. DM and no-DM cases were identified from comorbidity data. Univariate and multivariable analysis was performed. Multiple imputation method was employed to account for missing variables. Results: Of 8,466 cases of pancreatic cancer DM status was known in 4728 cases that comprised this analysis. Males accounted for 97.7% cases, and 78% were white. Overall survival was 4.2 months in DM group and 3.6 months in the no-DM group. In multivariable analysis, DM had a HR = 0.91 (0.849-0.974). This finding persisted after accounting for missing variables using multiple imputations method with the HR in DM group of 0.93 (0.867-0.997). Conclusions: Our data suggest DM is associated with a reduction in risk of death in pancreatic cancer. Future studies should be directed towards examining this association, specifically impact of DM medications on cancer outcome.

UR - http://www.scopus.com/inward/record.url?scp=84902340045&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902340045&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0098511

DO - 10.1371/journal.pone.0098511

M3 - Article

VL - 9

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 5

M1 - e98511

ER -