Impact of prior outpatient antibiotic use on mortality for community acquired pneumonia: A retrospective cohort study

Eric M. Mortensen, Marcos I. Restrepo, Jacqueline A. Pugh, Antonio Anzueto

Research output: Contribution to journalArticle

6 Scopus citations


Background. The purpose of this study was to examine whether prior outpatient antibiotic use is associated with increased 30-day mortality, after adjusting for potential confounders, for those subsequently hospitalized with pneumonia. Methods. A retrospective cohort study conducted at two tertiary teaching hospitals. Eligible subjects were admitted with a diagnosis of, and had a chest x-ray consistent with, community-acquired pneumonia. Our primary analysis was a multivariable logistic regression with the dependent variable of 30-day mortality. Results. Data was abstracted on 733 subjects at the two hospitals. Mortality was 8.1% at 30-days. At presentation, 55% of subjects were low risk, 33% were moderate risk, and 12% were high risk. In our cohort 17% (n = 128) of subjects received antibiotics within 30-days of presentation. Unadjusted mortality for those who had received prior antibiotics was 7.0% vs. 8.3% for those who had not (p = 0.6). In the multivariable analysis prior use of antibiotics (odds ratio 0.98, 95% confidence interval 0.5-2.1) was not significantly associated with 30-day mortality. Conclusion. Receipt of prior outpatient antibiotics is not significantly associated with 30-day mortality for patients hospitalized with pneumonia. Our study supports current efforts to increase the number of patients with pneumonia who are treated as outpatients.

Original languageEnglish (US)
Article number120
JournalBMC Research Notes
Publication statusPublished - 2008


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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