TY - JOUR
T1 - Impact of sex on outcomes of percutaneous coronary intervention for chronic total occlusion
T2 - A meta-analysis
AU - Latif, Azka
AU - Ahsan, Muhammad Junaid
AU - Lateef, Noman
AU - Aurit, Sarah
AU - Mirza, Mohsin M.
AU - Siller-Matula, Jolanta M.
AU - Mamas, Mamas A.
AU - Parikh, Manish
AU - Brilakis, Emmanouil S.
AU - Abbott, J. Dawn
AU - Bhatt, Deepak L.
AU - Velagapudi, Poonam
N1 - Publisher Copyright:
© 2021 Wiley Periodicals LLC.
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Background: Women are underrepresented in chronic total occlusion (CTO) trials and little is known about sex differences in the outcomes of CTO percutaneous coronary intervention (PCI). This meta-analysis aims to compare the outcomes of CTO PCI in males and females. Methods: A comprehensive search of PubMed, EMBASE, Cochrane, Web of Science, and Google Scholar was performed for studies comparing outcomes of CTO PCI in females versus males from inception to January 26, 2021. The current statistical analysis was performed using STATA version 15.1 software (Stata Corporation, TX); P < 0.05 indicated statistical significance. Results: Fourteen observational studies were included in the analysis with 75% males and 25% females. The mean age was 64.47 ± 10.5 years and 68.98 ± 9.5 years for males and females, respectively. The median follow-up duration was 2.4 years. Males had a higher Japanese-CTO (J-CTO) score compared with females (MD = −0.17; 95% CI: −0.25 to −0.10). Females had statistically higher success rates of CTO PCI (RR = 1.03; 95% CI: 1.01 to1.05), required less contrast volume (MD = −18.64: 95% CI: −30.89 to −6.39) and fluoroscopy time (MD = −9.12; 95% CI: −16.90 to −1.34) compared with males. There was no statistical difference in in-hospital (RR = 1.50; 95% CI: 0.73 to 3.09) or longer term (≥6 months) all-cause mortality (RR = 1.10; 95% CI: 0.86 to 1.42) between the two groups. Conclusions: CTO PCI is feasible and safe in female patients with comparable outcomes in female versus male patients.
AB - Background: Women are underrepresented in chronic total occlusion (CTO) trials and little is known about sex differences in the outcomes of CTO percutaneous coronary intervention (PCI). This meta-analysis aims to compare the outcomes of CTO PCI in males and females. Methods: A comprehensive search of PubMed, EMBASE, Cochrane, Web of Science, and Google Scholar was performed for studies comparing outcomes of CTO PCI in females versus males from inception to January 26, 2021. The current statistical analysis was performed using STATA version 15.1 software (Stata Corporation, TX); P < 0.05 indicated statistical significance. Results: Fourteen observational studies were included in the analysis with 75% males and 25% females. The mean age was 64.47 ± 10.5 years and 68.98 ± 9.5 years for males and females, respectively. The median follow-up duration was 2.4 years. Males had a higher Japanese-CTO (J-CTO) score compared with females (MD = −0.17; 95% CI: −0.25 to −0.10). Females had statistically higher success rates of CTO PCI (RR = 1.03; 95% CI: 1.01 to1.05), required less contrast volume (MD = −18.64: 95% CI: −30.89 to −6.39) and fluoroscopy time (MD = −9.12; 95% CI: −16.90 to −1.34) compared with males. There was no statistical difference in in-hospital (RR = 1.50; 95% CI: 0.73 to 3.09) or longer term (≥6 months) all-cause mortality (RR = 1.10; 95% CI: 0.86 to 1.42) between the two groups. Conclusions: CTO PCI is feasible and safe in female patients with comparable outcomes in female versus male patients.
KW - chronic total occlusion
KW - coronary artery disease
KW - gender/sex difference
KW - meta-analysis
KW - outcomes
KW - percutaneous coronary intervention
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U2 - 10.1002/ccd.30017
DO - 10.1002/ccd.30017
M3 - Article
C2 - 34767299
AN - SCOPUS:85119148541
SN - 1522-1946
VL - 99
SP - 254
EP - 262
JO - Catheterization and Cardiovascular Interventions
JF - Catheterization and Cardiovascular Interventions
IS - 2
ER -