Impaired cued and contextual memory in NPAS2-deficient mice

Joseph A. Garcia, Di Zhang, Sandi Jo Estill, Carolyn Michnoff, Jared Rutter, Martin Reick, Kristin Scott, Ramon Diaz-Arrastia, Steven L. McKnight

Research output: Contribution to journalArticle

160 Scopus citations

Abstract

Neuronal PAS domain protein 2 (NPAS2) is a basic helix-loop-helix (bHLH) PAS domain transcription factor expressed in multiple regions of the vertebrate brain. Targeted insertion of a β-galactosidase reporter gene (lacZ) resulted in the production of an NPAS2-lacZ fusion protein and an altered form of NPAS2 lacking the bHLH domain. The neuroanatomical expression pattern of NPAS2-lacZ was temporally and spatially coincident with formation of the mature frontal association/limbic forebrain pathway. NPAS2-deficient mice were subjected to a series of behavioral tests and were found to exhibit deficits in the long-term memory arm of the cued and contextual fear task. Thus, NPAS2 may serve a dedicated regulatory role in the acquisition of specific types of memory.

Original languageEnglish (US)
Pages (from-to)2226-2230
Number of pages5
JournalScience
Volume288
Issue number5474
DOIs
StatePublished - Jun 23 2000

ASJC Scopus subject areas

  • General

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    Garcia, J. A., Zhang, D., Estill, S. J., Michnoff, C., Rutter, J., Reick, M., Scott, K., Diaz-Arrastia, R., & McKnight, S. L. (2000). Impaired cued and contextual memory in NPAS2-deficient mice. Science, 288(5474), 2226-2230. https://doi.org/10.1126/science.288.5474.2226