Impaired Thermoregulatory Function during Dynamic Exercise in Multiple Sclerosis

Dustin R. Allen, Mu Huang, Nathan B. Morris, Georgia K. Chaseling, Elliot Frohman, Ollie Jay, Scott L. Davis

Research output: Contribution to journalArticle

Abstract

Introduction Impairments in sudomotor function during passive whole-body heating have been reported in multiple sclerosis (MS), a demyelinating disease of the CNS that disrupts autonomic function. However, the capability of the thermoregulatory system to control body temperature during exercise has never been assessed in MS. Thus, the aim of the present study was to test the hypothesis that thermoregulatory function is impaired in MS patients compared with healthy controls (CON) exercising at similar rates of metabolic heat production. Methods Sweating and skin blood flow responses were compared between 12 individuals diagnosed with relapsing-remitting MS (9 females, 3 males) and 12 sex-, age-, mass-, and BSA-matched CON during a single bout of cycling exercise (rate of metabolic heat production: ∼4.5 W·kg -1 ) for 60 min in a climate-controlled room (25°C, 30% RH). Results Individuals with MS exhibited an attenuated increase in cumulative whole-body sweat loss after 30 min (MS, 72 ± 51 g; CON, 104 ± 37 g; P = 0.04) and 60 min (MS, 209 ± 94 g; CON, 285 ± 62 g; P = 0.02), as well as lower sweating thermosensitivity (MS, 0.49 ± 0.26 mg·cm -2 ·min -1 ·°C -1 ; CON, 0.86 ± 0.30 mg·cm -2 ·min -1 ·°C -1 ; P = 0.049). Despite evidence for thermoregulatory dysfunction, there were no differences between MS and CON in esophageal or rectal temperatures at 30-or 60-min time points (P > 0.05). Cutaneous vasculature responses were also not different in MS compared with CON (P > 0.05). Conclusion Taken together, MS blunts sweating responses during exercise while cutaneous vasculature responses are preserved. Altered mechanisms of body temperature regulation in persons with MS may lead to temporary worsening of disease symptoms and limit exercise tolerance under more thermally challenging conditions.

Original languageEnglish (US)
Pages (from-to)395-404
Number of pages10
JournalMedicine and science in sports and exercise
Volume51
Issue number3
DOIs
StatePublished - Mar 1 2019

Keywords

  • AUTONOMIC DYSFUNCTION
  • PHYSICAL ACTIVITY
  • SKIN BLOOD FLOW
  • SWEAT RATE
  • THERMOSENSITIVITY

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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