Impairments in spatial memory retention of GFAP-apoE4 female mice

Peter van Meer, Summer Acevedo, Jacob Raber

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The human apolipoprotein E isoforms, apoE2, apoE3, and apoE4, have differential effects on brain function. Compared to apoE3, apoE4 increases the risk of age-related cognitive decline in humans and female mice expressing apoE in neurons. Here, we show impaired spatial memory retention in female mice expressing apoE4 in astrocytes compared to those expressing apoE3 in astrocytes or lacking apoE. Thus, apoE4 impairs cognition whether expressed in neurons or astrocytes.

Original languageEnglish (US)
Pages (from-to)372-375
Number of pages4
JournalBehavioural Brain Research
Volume176
Issue number2
DOIs
StatePublished - Jan 25 2007

Fingerprint

Apolipoprotein E4
Apolipoprotein E3
Apolipoproteins E
Astrocytes
Apolipoprotein E2
Neurons
Cognition
Protein Isoforms
Spatial Memory
Retention (Psychology)
Brain

Keywords

  • Apolipoprotein E
  • Passive avoidance
  • Rotorod
  • Transgenic mice
  • Water maze

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Impairments in spatial memory retention of GFAP-apoE4 female mice. / van Meer, Peter; Acevedo, Summer; Raber, Jacob.

In: Behavioural Brain Research, Vol. 176, No. 2, 25.01.2007, p. 372-375.

Research output: Contribution to journalArticle

van Meer, Peter ; Acevedo, Summer ; Raber, Jacob. / Impairments in spatial memory retention of GFAP-apoE4 female mice. In: Behavioural Brain Research. 2007 ; Vol. 176, No. 2. pp. 372-375.
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