Impairments in spatial memory retention of GFAP-apoE4 female mice

Peter van Meer, Summer Acevedo, Jacob Raber

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The human apolipoprotein E isoforms, apoE2, apoE3, and apoE4, have differential effects on brain function. Compared to apoE3, apoE4 increases the risk of age-related cognitive decline in humans and female mice expressing apoE in neurons. Here, we show impaired spatial memory retention in female mice expressing apoE4 in astrocytes compared to those expressing apoE3 in astrocytes or lacking apoE. Thus, apoE4 impairs cognition whether expressed in neurons or astrocytes.

Original languageEnglish (US)
Pages (from-to)372-375
Number of pages4
JournalBehavioural Brain Research
Volume176
Issue number2
DOIs
StatePublished - Jan 25 2007

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Keywords

  • Apolipoprotein E
  • Passive avoidance
  • Rotorod
  • Transgenic mice
  • Water maze

ASJC Scopus subject areas

  • Behavioral Neuroscience

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