Improvement in tardive dyskinesia after muscimol therapy

C. A. Tamminga, J. W. Crayton, T. N. Chase

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Abstract

Muscimol, thought to be an agonist of γ-aminobutyric acid (GABA), was administered to eight neuroleptic-free subjects with tardive dyskinesia. At oral dose levels from 5 to 9 mg, involuntary movements were consistently attenuated, usually in the absence of sedation. These results support the view that pharmacologic attempts to stimulate GABA-mediated synaptic transmission may afford synptomatic relief to patients with tardive dyskinesia.

Original languageEnglish (US)
Pages (from-to)595-598
Number of pages4
JournalArchives of General Psychiatry
Volume36
Issue number5
StatePublished - 1979

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ASJC Scopus subject areas

  • Psychiatry and Mental health

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