Improving BP control with combined renin-angiotensin system blockade and thiazide diuretics in hypertensive patients with diabetes mellitus or kidney disease

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11 Citations (Scopus)

Abstract

Most hypertensive patients will require more than one antihypertensive drug to lower BP below target levels. The combination of diuretics with renin-angiotensin system (RAS) antagonists offers several advantages to include additive BP-lowering efficacy and enhanced reductions in urinary protein excretion. Thiazide diuretics are associated with metabolic complications that are particularly evident when used in high doses. When used in combination with RAS blockade, metabolic complications such as hypokalemia are minimized. The avoidance of hypokalemia has been linked to less thiazide-induced glucose intolerance. Patient persistence on therapy is dependent on well tolerated drug combinations.

Original languageEnglish (US)
Pages (from-to)9-14
Number of pages6
JournalAmerican Journal of Cardiovascular Drugs
Volume8
Issue number1
DOIs
StatePublished - 2008

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Sodium Chloride Symporter Inhibitors
Hypokalemia
Kidney Diseases
Renin-Angiotensin System
Diabetes Mellitus
Thiazides
Glucose Intolerance
Drug Combinations
Diuretics
Antihypertensive Agents
Proteins
Therapeutics

Keywords

  • ACE inhibitors, therapeutic use
  • Angiotensin receptor antagonists, therapeutic use
  • Diabetes mellitus
  • Hypertension, treatment
  • Kidney disorders
  • Losartan/hydrochlorothiazide, therapeutic use
  • Olmesartan medoxomil/ hydrochlorothiazide, therapeutic use

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

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