Improving BP control with combined renin-angiotensin system blockade and thiazide diuretics in hypertensive patients with diabetes mellitus or kidney disease

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Most hypertensive patients will require more than one antihypertensive drug to lower BP below target levels. The combination of diuretics with renin-angiotensin system (RAS) antagonists offers several advantages to include additive BP-lowering efficacy and enhanced reductions in urinary protein excretion. Thiazide diuretics are associated with metabolic complications that are particularly evident when used in high doses. When used in combination with RAS blockade, metabolic complications such as hypokalemia are minimized. The avoidance of hypokalemia has been linked to less thiazide-induced glucose intolerance. Patient persistence on therapy is dependent on well tolerated drug combinations.

Original languageEnglish (US)
Pages (from-to)9-14
Number of pages6
JournalAmerican Journal of Cardiovascular Drugs
Volume8
Issue number1
DOIs
StatePublished - Mar 4 2008

Keywords

  • ACE inhibitors, therapeutic use
  • Angiotensin receptor antagonists, therapeutic use
  • Diabetes mellitus
  • Hypertension, treatment
  • Kidney disorders
  • Losartan/hydrochlorothiazide, therapeutic use
  • Olmesartan medoxomil/ hydrochlorothiazide, therapeutic use

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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