In and out: Histone variant exchange in chromatin

Jingji Jin, Yong Cai, Bing Li, Ronald C. Conaway, Jerry L. Workman, Joan Weliky Conaway, Thomas Kusch

Research output: Contribution to journalReview article

120 Scopus citations

Abstract

Alterations in nucleosome structure affect the accessibility of the DNA and can generate specialized domains of chromatin in the genome. Such changes can be introduced by posttranslational modifications of histones, by chromatin remodeling, or by the incorporation of variants of H2A and H3 into nucleosomes. In contrast to the canonical histones, which are deposited behind the replication fork during S phase, histone variants are incorporated in a process that is independent of DNA replication. Recent studies have shown that distinct multiprotein complexes are responsible for the targeted deposition of histone variants at active genes, centromeres and silent loci. The incorporation of histone variants most probably has epigenetic consequences and contributes to architectural changes in chromosomes.

Original languageEnglish (US)
Pages (from-to)680-687
Number of pages8
JournalTrends in Biochemical Sciences
Volume30
Issue number12
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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    Jin, J., Cai, Y., Li, B., Conaway, R. C., Workman, J. L., Conaway, J. W., & Kusch, T. (2005). In and out: Histone variant exchange in chromatin. Trends in Biochemical Sciences, 30(12), 680-687. https://doi.org/10.1016/j.tibs.2005.10.003