@article{9abfc6df4a994ecdaba529b8322d347b,
title = "In vivo estimation of transverse relaxation time constant (T2) of 17 human brain metabolites at 3T",
abstract = "Purpose: The transverse relaxation times T2 of 17 metabolites in vivo at 3T is reported and region specific differences are addressed. Methods: An echo-time series protocol was applied to one, two, or three volumes of interest with different fraction of white and gray matter including a total number of 106 healthy volunteers and acquiring a total number of 128 spectra. The data were fitted with the 2D fitting tool ProFit2, which included individual line shape modeling for all metabolites and allowed the T2 calculation of 28 moieties of 17 metabolites. Results: The T2 of 10 metabolites and their moieties have been reported for the first time. Region specific T2 differences in white and gray matter enriched tissue occur in 16 of 17 metabolites examined including single resonance lines and coupled spin systems. Conclusion: The relaxation time T2 is regions specific and has to be considered when applying tissue composition correction for internal water referencing. Magn Reson Med 80:452–461, 2018.",
keywords = "3T, T correction, T relaxation time, gray and white matter, human, in vivo",
author = "Wyss, {Patrik O.} and Claudio Bianchini and Milan Scheidegger and Giapitzakis, {Ioannis A.} and Andreas Hock and Alexander Fuchs and Anke Henning",
note = "Funding Information: 1Institute for Biomedical Engineering, University and ETH, Zurich, Switzerland. 2Max Planck Institute for Biological Cybernetics, Tuebingen, Germany. 3Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. 4Institute of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany. Grant sponsor: Swiss National Science Foundation; Grant number: 143715; Grant sponsor: University Zurich: Clinical Research Priority Program Multiple Sclerosis; Grant sponsor: ERC Starting Grant; Grant number: SYNA-PLAST MR: 679927. *Correspondence to: Patrik Wyss, M.Sc. ETH, ETH and University Zurich, Institute for Biomedical Engineering, Gloriastrasse 35, 8092 Zurich, Switzerland. E-mail: pawyss@biomed.ee.ethz.ch Received 4 September 2017; revised 8 December 2017; accepted 9 December 2017 DOI 10.1002/mrm.27067 Published online 17 January 2018 in Wiley Online Library (wileyonlinelibrary. com). Publisher Copyright: {\textcopyright} 2018 International Society for Magnetic Resonance in Medicine",
year = "2018",
month = aug,
doi = "10.1002/mrm.27067",
language = "English (US)",
volume = "80",
pages = "452--461",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "2",
}