In vivo functional photoacoustic tomography of traumatic brain injury in rats

Jung Taek Oh, Kwang Hyun Song, Meng Lin Li, George Stoica, Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this study, we demonstrate the potential of photoacoustic tomography for the study of traumatic brain injury (TBI) in rats in vivo. Based on spectroscopic photoacoustic tomography that can detect the absorption rates of oxy- and deoxyhemoglobins, the blood oxygen saturation and total blood volume in TBI rat brains were visualized. Reproducible cerebral trauma was induced using a fluid percussion TBI device. The time courses of the hemodynamic response following the trauma initiation were imaged with multi-wavelength photoacoustic tomography with bandwidth-limited spatial resolution through the intact skin and skull. In the pilot set of experiments, trauma induced hematomas and blood oxygen saturation level changes were detected, a finding consistent with the known physiological responses to TBI. This new imaging method will be useful for future studies on TBI-related metabolic activities and the effects of therapeutic agents.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
DOIs
StatePublished - May 8 2006
Event7th Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - Photons Plus Ultrasound: Imaging and Sensing 2006 - San Jose, CA, United States
Duration: Jan 22 2006Jan 26 2006

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume6086
ISSN (Print)0277-786X

Other

Other7th Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - Photons Plus Ultrasound: Imaging and Sensing 2006
CountryUnited States
CitySan Jose, CA
Period1/22/061/26/06

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Keywords

  • Blood oxygenation
  • Blood volume
  • Photoacoustic tomography
  • Spectroscopic imaging
  • Traumatic brain injury

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Oh, J. T., Song, K. H., Li, M. L., Stoica, G., & Wang, L. V. (2006). In vivo functional photoacoustic tomography of traumatic brain injury in rats. In Proceedings of SPIE - The International Society for Optical Engineering [60860P] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6086). https://doi.org/10.1117/12.645378