@inproceedings{c5c99b28216b4ff79d5b4c338e6f25cd,
title = "In vivo functional photoacoustic tomography of traumatic brain injury in rats",
abstract = "In this study, we demonstrate the potential of photoacoustic tomography for the study of traumatic brain injury (TBI) in rats in vivo. Based on spectroscopic photoacoustic tomography that can detect the absorption rates of oxy- and deoxyhemoglobins, the blood oxygen saturation and total blood volume in TBI rat brains were visualized. Reproducible cerebral trauma was induced using a fluid percussion TBI device. The time courses of the hemodynamic response following the trauma initiation were imaged with multi-wavelength photoacoustic tomography with bandwidth-limited spatial resolution through the intact skin and skull. In the pilot set of experiments, trauma induced hematomas and blood oxygen saturation level changes were detected, a finding consistent with the known physiological responses to TBI. This new imaging method will be useful for future studies on TBI-related metabolic activities and the effects of therapeutic agents.",
keywords = "Blood oxygenation, Blood volume, Photoacoustic tomography, Spectroscopic imaging, Traumatic brain injury",
author = "Oh, {Jung Taek} and Song, {Kwang Hyun} and Li, {Meng Lin} and George Stoica and Wang, {Lihong V.}",
year = "2006",
month = mar,
day = "6",
doi = "10.1117/12.645378",
language = "English (US)",
isbn = "0819461288",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
booktitle = "Photons Plus Ultrasound",
note = "7th Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - Photons Plus Ultrasound: Imaging and Sensing 2006 ; Conference date: 22-01-2006 Through 26-01-2006",
}