In vivo phosphorus-31 nuclear magnetic resonance study of the regional metabolic response to cardiac ischemia.

C. R. Malloy, P. M. Matthews, M. B. Smith, G. K. Radda

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We applied 31P nuclear magnetic resonance to the study of acute ischemia in vivo. In open-chest rabbits, the left anterior descending coronary artery was occluded after control spectra were obtained. Phosphocreatine concentration decreased in the first minute and ATP concentration declined subsequently, and pH decreased to 5.8 within 20 min. Intracellular acidosis was greater than that previously reported for the isolated perfused rabbit heart.

Original languageEnglish (US)
Pages (from-to)461-464
Number of pages4
JournalAdvances in myocardiology
Volume6
StatePublished - 1985

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Phosphorus
Magnetic Resonance Spectroscopy
Ischemia
Rabbits
Phosphocreatine
Acidosis
Coronary Vessels
Thorax
Adenosine Triphosphate

ASJC Scopus subject areas

  • Medicine(all)

Cite this

In vivo phosphorus-31 nuclear magnetic resonance study of the regional metabolic response to cardiac ischemia. / Malloy, C. R.; Matthews, P. M.; Smith, M. B.; Radda, G. K.

In: Advances in myocardiology, Vol. 6, 1985, p. 461-464.

Research output: Contribution to journalArticle

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