In vivo stereological assessment of human cerebellar volume: Effects of gender and age

P. R. Escalona, W. M. McDonald, P. M. Doraiswamy, O. B. Boyko, M. M. Husain, G. S. Figiel, D. Laskowitz, E. H. Ellinwood, K. R R Krishnan

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Intermediate T2-weighted MR images and a systematic sampling stereological method were used in 37 normal volunteers, 24 to 79 years old, to assess the effects of age and sex on cerebellar volume. Female subjects (n = 21) had significantly smaller cerebellar volumes compared with males (n = 16) of similar age (t = -3.9, p < .0008, two-tail t test). Using straight-line, univariate regression, we determined that age was not a significant predictor of cerebellar volume (R2 = 0.07, t = -1.66, p = 0.11), whereas gender did appear to account for a significant amount of variability in cerebellar volume (R2 = 0.33, t = -4.13, p = .0002). The mean absolute cerebellar volume in this study was 112 ml (SD ± 16) for all subjects, 104 ml (SD ± 10) for females, and 122 ml (SD ± 16) for males. This study demonstrates the feasibility of using MR images along with a systematic stereological method to assess in vivo human cerebellar volume, thereby providing a research tool to correlate cerebellar morphology with cognitive and neuromotor function.

Original languageEnglish (US)
Pages (from-to)927-929
Number of pages3
JournalAmerican Journal of Neuroradiology
Issue number5
Publication statusPublished - 1991


ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Escalona, P. R., McDonald, W. M., Doraiswamy, P. M., Boyko, O. B., Husain, M. M., Figiel, G. S., ... Krishnan, K. R. R. (1991). In vivo stereological assessment of human cerebellar volume: Effects of gender and age. American Journal of Neuroradiology, 12(5), 927-929.