Inadequate Response to Treatment in Major Depressive Disorder: Augmentation and Adjunctive Strategies

Roueen Rafeyan, George I. Papakostas, W. Clay Jackson, Madhukar H. Trivedi

Research output: Contribution to journalArticle

Abstract

​​​​ About 30%-50% of patients experience inadequate response to antidepressant therapy, and treatment choices for these patients include augmenting the antidepressant with another therapy, increasing the dose, switching to a different antidepressant, or combining antidepressants. Clinicians should tailor treatment strategies based on patients' response, tolerability, and disease severity. In this activity, augmentation and adjunctive strategies involving atypical antipsychotics, as well as off-label options including buspirone, stimulants, thyroid hormone, and lithium, are reviewed.​ ​.

Original languageEnglish (US)
JournalThe Journal of clinical psychiatry
Issue number3
DOIs
StatePublished - May 12 2020

ASJC Scopus subject areas

  • Psychiatry and Mental health

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