TY - JOUR
T1 - Inadequate Response to Treatment in Major Depressive Disorder
T2 - Augmentation and Adjunctive Strategies
AU - Rafeyan, Roueen
AU - Papakostas, George I.
AU - Jackson, W. Clay
AU - Trivedi, Madhukar H.
N1 - Publisher Copyright:
© Copyright 2020 Physicians Postgraduate Press, Inc.
Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2020/5/12
Y1 - 2020/5/12
N2 - About 30%-50% of patients experience inadequate response to antidepressant therapy, and treatment choices for these patients include augmenting the antidepressant with another therapy, increasing the dose, switching to a different antidepressant, or combining antidepressants. Clinicians should tailor treatment strategies based on patients' response, tolerability, and disease severity. In this activity, augmentation and adjunctive strategies involving atypical antipsychotics, as well as off-label options including buspirone, stimulants, thyroid hormone, and lithium, are reviewed. .
AB - About 30%-50% of patients experience inadequate response to antidepressant therapy, and treatment choices for these patients include augmenting the antidepressant with another therapy, increasing the dose, switching to a different antidepressant, or combining antidepressants. Clinicians should tailor treatment strategies based on patients' response, tolerability, and disease severity. In this activity, augmentation and adjunctive strategies involving atypical antipsychotics, as well as off-label options including buspirone, stimulants, thyroid hormone, and lithium, are reviewed. .
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U2 - 10.4088/JCP.OT19037BR3
DO - 10.4088/JCP.OT19037BR3
M3 - Review article
C2 - 32412697
AN - SCOPUS:85084786665
SN - 0160-6689
VL - 81
JO - The Journal of clinical psychiatry
JF - The Journal of clinical psychiatry
IS - 3
ER -