TY - JOUR
T1 - Incidence of cardiovascular events after hospital admission for pneumonia
AU - Perry, Theodore W.
AU - Pugh, Mary Jo V
AU - Waterer, Grant W.
AU - Nakashima, Brandy
AU - Orihuela, Carlos J.
AU - Copeland, Laurel A.
AU - Restrepo, Marcos I.
AU - Anzueto, Antonio
AU - Mortensen, Eric M.
N1 - Funding Information:
Funding: The project described was supported by Grant R01NR010828 from the National Institute of Nursing Research . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Nursing Research or the National Institutes of Health. This material is the result of work supported with resources and the use of facilities at the South Texas Veterans Health Care System . Dr Restrepo is supported by a Department of Veteran Affairs Veterans Integrated Service Network 17 new faculty grant and National Health Institutes Grant KL2 RR025766 . The funding agencies had no role in conducting the study or in the preparation, review, or approval of the manuscript. The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs.
PY - 2011/3
Y1 - 2011/3
N2 - Objective: Several studies have suggested an increased risk of cardiovascular events, primarily acute myocardial infarction, around the time of hospital admission for pneumonia. Therefore, we examined cardiovascular events, including myocardial infarction, congestive heart failure, unstable angina, stroke, and serious cardiac arrhythmias, within 90 days after hospitalization for pneumonia. Methods: By using data from the administrative databases of the Department of Veterans Affairs, we examined a cohort of subjects hospitalized with pneumonia between October 2001 and September 2007. Subjects were at least 65 years of age. We examined the incidence of myocardial infarction, congestive heart failure, cardiac arrhythmias, unstable angina, and stroke by International Classification of Diseases, Ninth Revision codes, excluding those with a diagnosis before the admission for pneumonia. Results: The cohort comprised 50,119 subjects with a mean age of 77.5 years (standard deviation 6.7 years), 98% of whom were male. The 90-day incidence of cardiovascular events was 1.5% for myocardial infarction, 10.2% for congestive heart failure, 9.5% for arrhythmia, 0.8% for unstable angina, and 0.2% for stroke. The majority of events occurred during the hospitalization for pneumonia. Conclusion: A clinically important number of subjects in this cohort had a cardiovascular event within 90 days of hospital admission, suggesting that such events may have an important role in post-pneumonia mortality. Additional research is needed to determine whether interventions may reduce the number of cardiovascular events after pneumonia.
AB - Objective: Several studies have suggested an increased risk of cardiovascular events, primarily acute myocardial infarction, around the time of hospital admission for pneumonia. Therefore, we examined cardiovascular events, including myocardial infarction, congestive heart failure, unstable angina, stroke, and serious cardiac arrhythmias, within 90 days after hospitalization for pneumonia. Methods: By using data from the administrative databases of the Department of Veterans Affairs, we examined a cohort of subjects hospitalized with pneumonia between October 2001 and September 2007. Subjects were at least 65 years of age. We examined the incidence of myocardial infarction, congestive heart failure, cardiac arrhythmias, unstable angina, and stroke by International Classification of Diseases, Ninth Revision codes, excluding those with a diagnosis before the admission for pneumonia. Results: The cohort comprised 50,119 subjects with a mean age of 77.5 years (standard deviation 6.7 years), 98% of whom were male. The 90-day incidence of cardiovascular events was 1.5% for myocardial infarction, 10.2% for congestive heart failure, 9.5% for arrhythmia, 0.8% for unstable angina, and 0.2% for stroke. The majority of events occurred during the hospitalization for pneumonia. Conclusion: A clinically important number of subjects in this cohort had a cardiovascular event within 90 days of hospital admission, suggesting that such events may have an important role in post-pneumonia mortality. Additional research is needed to determine whether interventions may reduce the number of cardiovascular events after pneumonia.
KW - Cardiac arrhythmia
KW - Cardiovascular disease
KW - Congestive heart failure
KW - Myocardial infarction
KW - Pneumonia
UR - http://www.scopus.com/inward/record.url?scp=79952458112&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952458112&partnerID=8YFLogxK
U2 - 10.1016/j.amjmed.2010.11.014
DO - 10.1016/j.amjmed.2010.11.014
M3 - Article
C2 - 21396508
AN - SCOPUS:79952458112
SN - 0002-9343
VL - 124
SP - 244
EP - 251
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 3
ER -