Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers

Florencia Pereyra, Janet Lo, Virginia A. Triant, Jeffrey Wei, Maria J. Buzon, Kathleen V. Fitch, Janice Hwang, Jennifer H. Campbell, Tricia H. Burdo, Kenneth C. Williams, Suhny Abbara, Steven K. Grinspoon

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

HIV-1 elite controllers spontaneously maintain suppressed levels of viremia, but exhibit significant immune activation. We investigated coronary atherosclerosis by coronary computed tomography angiography (CTA) in elite controllers, nonelite controller, chronically HIV-1 infected, antiretroviral therapy (ART)-treated patients with undetectable viral load ('chronic HIV'), and HIV-negative controls. Prevalence of atherosclerosis (78 vs. 42%, P < 0.05) and markers of immune activation were increased in elite controllers compared with HIV-negative controls. sCD163, a monocyte activation marker, was increased in elite controllers compared with chronic HIV-1 (P < 0.05) and compared with HIV-negative controls (P < 0.05). These data suggest a significant degree of coronary atherosclerosis and monocyte activation among elite controllers.

Original languageEnglish (US)
Pages (from-to)2409-2412
Number of pages4
JournalAIDS
Volume26
Issue number18
DOIs
StatePublished - Nov 28 2012

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HIV-1
Coronary Artery Disease
HIV
Monocytes
Viremia
Viral Load
Atherosclerosis
Biomarkers
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Pereyra, F., Lo, J., Triant, V. A., Wei, J., Buzon, M. J., Fitch, K. V., ... Grinspoon, S. K. (2012). Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers. AIDS, 26(18), 2409-2412. https://doi.org/10.1097/QAD.0b013e32835a9950

Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers. / Pereyra, Florencia; Lo, Janet; Triant, Virginia A.; Wei, Jeffrey; Buzon, Maria J.; Fitch, Kathleen V.; Hwang, Janice; Campbell, Jennifer H.; Burdo, Tricia H.; Williams, Kenneth C.; Abbara, Suhny; Grinspoon, Steven K.

In: AIDS, Vol. 26, No. 18, 28.11.2012, p. 2409-2412.

Research output: Contribution to journalArticle

Pereyra, F, Lo, J, Triant, VA, Wei, J, Buzon, MJ, Fitch, KV, Hwang, J, Campbell, JH, Burdo, TH, Williams, KC, Abbara, S & Grinspoon, SK 2012, 'Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers', AIDS, vol. 26, no. 18, pp. 2409-2412. https://doi.org/10.1097/QAD.0b013e32835a9950
Pereyra F, Lo J, Triant VA, Wei J, Buzon MJ, Fitch KV et al. Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers. AIDS. 2012 Nov 28;26(18):2409-2412. https://doi.org/10.1097/QAD.0b013e32835a9950
Pereyra, Florencia ; Lo, Janet ; Triant, Virginia A. ; Wei, Jeffrey ; Buzon, Maria J. ; Fitch, Kathleen V. ; Hwang, Janice ; Campbell, Jennifer H. ; Burdo, Tricia H. ; Williams, Kenneth C. ; Abbara, Suhny ; Grinspoon, Steven K. / Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers. In: AIDS. 2012 ; Vol. 26, No. 18. pp. 2409-2412.
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