Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers

Florencia Pereyra, Janet Lo, Virginia A. Triant, Jeffrey Wei, Maria J. Buzon, Kathleen V. Fitch, Janice Hwang, Jennifer H. Campbell, Tricia H. Burdo, Kenneth C. Williams, Suhny Abbara, Steven K. Grinspoon

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113 Scopus citations

Abstract

HIV-1 elite controllers spontaneously maintain suppressed levels of viremia, but exhibit significant immune activation. We investigated coronary atherosclerosis by coronary computed tomography angiography (CTA) in elite controllers, nonelite controller, chronically HIV-1 infected, antiretroviral therapy (ART)-treated patients with undetectable viral load ('chronic HIV'), and HIV-negative controls. Prevalence of atherosclerosis (78 vs. 42%, P < 0.05) and markers of immune activation were increased in elite controllers compared with HIV-negative controls. sCD163, a monocyte activation marker, was increased in elite controllers compared with chronic HIV-1 (P < 0.05) and compared with HIV-negative controls (P < 0.05). These data suggest a significant degree of coronary atherosclerosis and monocyte activation among elite controllers.

Original languageEnglish (US)
Pages (from-to)2409-2412
Number of pages4
JournalAIDS
Volume26
Issue number18
DOIs
StatePublished - Nov 28 2012

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Pereyra, F., Lo, J., Triant, V. A., Wei, J., Buzon, M. J., Fitch, K. V., Hwang, J., Campbell, J. H., Burdo, T. H., Williams, K. C., Abbara, S., & Grinspoon, S. K. (2012). Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers. AIDS, 26(18), 2409-2412. https://doi.org/10.1097/QAD.0b013e32835a9950