Increased Endotoxin and Interleukin-1 ß Concentrations in Cerebrospinal Fluid of Infants with Coliform Meningitis and Ventriculitis Associated with Intraventricular Gentamicin Therapy

M. M. Mustafa, J. Mertsola, O. Ramilo, X. Saez-Llorens, R. C. Risser, G. H. McCracken

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

Intraventricular gentamicin therapy in infants with gram-negative enteric bacillary meningitis and ventriculitis is associated with increased mortality. Therefore, endotoxin, interleukin-1β, and cachectin (tumor necrosis factor) concentrations in ventricular cerebrospinal fluid from 21 infants (11 received intravenous antibiotics alone and 10 received intraventricular gentamicin also) were determined and correlated with outcome and other ventricular cerebrospinal fluid indexes of inflammation. Mean interleukin-1β concentrations in ventricular cerebrospinal fluid correlated significantly with adverse outcome and with mean concentrations of endotoxin, white blood cells, and protein and inversely with glucose concentrations. Mean and peak endotoxin and interleukin-1β concentrations were significantly higher in infants who received intraventricular gentamicin and intravenous antibiotics than in infants given intravenous antibiotics alone. Intraventricular gentamicin may have caused release of endotoxin from gram-negative bacilli in ventricular cerebrospinal fluid, resulting in increased interleukin-1β concentrations and inflammation, which could have contributed to the poor outcome in these patients.

Original languageEnglish (US)
Pages (from-to)891-895
Number of pages5
JournalJournal of Infectious Diseases
Volume160
Issue number5
DOIs
StatePublished - Nov 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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