TY - JOUR
T1 - Increased Endotoxin and Interleukin-1 ß Concentrations in Cerebrospinal Fluid of Infants with Coliform Meningitis and Ventriculitis Associated with Intraventricular Gentamicin Therapy
AU - Mustafa, M. M.
AU - Mertsola, J.
AU - Ramilo, O.
AU - Saez-Llorens, X.
AU - Risser, R. C.
AU - McCracken, G. H.
PY - 1989/11
Y1 - 1989/11
N2 - Intraventricular gentamicin therapy in infants with gram-negative enteric bacillary meningitis and ventriculitis is associated with increased mortality. Therefore, endotoxin, interleukin-1β, and cachectin (tumor necrosis factor) concentrations in ventricular cerebrospinal fluid from 21 infants (11 received intravenous antibiotics alone and 10 received intraventricular gentamicin also) were determined and correlated with outcome and other ventricular cerebrospinal fluid indexes of inflammation. Mean interleukin-1β concentrations in ventricular cerebrospinal fluid correlated significantly with adverse outcome and with mean concentrations of endotoxin, white blood cells, and protein and inversely with glucose concentrations. Mean and peak endotoxin and interleukin-1β concentrations were significantly higher in infants who received intraventricular gentamicin and intravenous antibiotics than in infants given intravenous antibiotics alone. Intraventricular gentamicin may have caused release of endotoxin from gram-negative bacilli in ventricular cerebrospinal fluid, resulting in increased interleukin-1β concentrations and inflammation, which could have contributed to the poor outcome in these patients.
AB - Intraventricular gentamicin therapy in infants with gram-negative enteric bacillary meningitis and ventriculitis is associated with increased mortality. Therefore, endotoxin, interleukin-1β, and cachectin (tumor necrosis factor) concentrations in ventricular cerebrospinal fluid from 21 infants (11 received intravenous antibiotics alone and 10 received intraventricular gentamicin also) were determined and correlated with outcome and other ventricular cerebrospinal fluid indexes of inflammation. Mean interleukin-1β concentrations in ventricular cerebrospinal fluid correlated significantly with adverse outcome and with mean concentrations of endotoxin, white blood cells, and protein and inversely with glucose concentrations. Mean and peak endotoxin and interleukin-1β concentrations were significantly higher in infants who received intraventricular gentamicin and intravenous antibiotics than in infants given intravenous antibiotics alone. Intraventricular gentamicin may have caused release of endotoxin from gram-negative bacilli in ventricular cerebrospinal fluid, resulting in increased interleukin-1β concentrations and inflammation, which could have contributed to the poor outcome in these patients.
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U2 - 10.1093/infdis/160.5.891
DO - 10.1093/infdis/160.5.891
M3 - Article
C2 - 2809260
AN - SCOPUS:0024458956
VL - 160
SP - 891
EP - 895
JO - The Journal of infectious diseases
JF - The Journal of infectious diseases
SN - 0022-1899
IS - 5
ER -