Increased superoxide generation by normal granulocytes incubated in sera from patients with psoriasis

J. B. Sedgwick, P. R. Bergstresser, E. R. Hurd

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Sera from patients with untreated psoriasis were found to induce increased superoxide anion (O2-) generation when incubated with normal granulocytes (PMNs) and zymosan. Sera from patients receiving systemic chemotherapy induced O2- generation which was similar to that of normal sera and significantly lower than sera from the untreated patients. O2- production was measured by suproxide dismutase inhibitable ferricytochrome C reductiona and was dependent on the presence of both zymosan and a heat labile serum factor. Serum C3c and C5 levels were elevated in both treated and untreated groups of psoriasis patients while C4 was elevated only in untreated patients. Serum ceruloplasmin, a O2- scavenger, was not decreased in patients with psoriasis, and consequently does not account for the increased O2- generation. These data suggest that sera from patients with psoriasis have an increased capacity to activate PMNs. Activation of PMNs in cutaneous and joint lesions may play a pathogenic role in psoriasis.

Original languageEnglish (US)
Pages (from-to)158-163
Number of pages6
JournalJournal of Investigative Dermatology
Volume76
Issue number3
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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